Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of …

MG Guzman, M Alvarez, SB Halstead - Archives of virology, 2013 - Springer
Today, dengue viruses are the most prevalent arthropod-borne viruses in the world. Since
the 1960s, numerous reports have identified a second heterologous dengue virus (DENV) …

Dengue virus pathogenesis: an integrated view

BEE Martina, P Koraka… - Clinical microbiology …, 2009 - Am Soc Microbiol
Much remains to be learned about the pathogenesis of the different manifestations of
dengue virus (DENV) infections in humans. They may range from subclinical infection to …

Antibody-dependent enhancement of severe dengue disease in humans

LC Katzelnick, L Gresh, ME Halloran, JC Mercado… - Science, 2017 - science.org
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus

JJ Waggoner, L Gresh, MJ Vargas… - Clinical Infectious …, 2016 - academic.oup.com
Background. Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV)
cocirculate in Nicaragua. In this study, we sought to compare the quantified viremia and …

Reconstruction of antibody dynamics and infection histories to evaluate dengue risk

H Salje, DAT Cummings, I Rodriguez-Barraquer… - Nature, 2018 - nature.com
As with many pathogens, most dengue infections are subclinical and therefore unobserved.
Coupled with limited understanding of the dynamic behaviour of potential serological …

Dengue infection

MG Guzman, DJ Gubler, A Izquierdo… - Nature reviews Disease …, 2016 - nature.com
Dengue is widespread throughout the tropics and local spatial variation in dengue virus
transmission is strongly influenced by rainfall, temperature, urbanization and distribution of …

Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators

EL Azeredo, RQ Monteiro… - Mediators of …, 2015 - Wiley Online Library
Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a
self‐limiting acute febrile illness followed by a phase of critical defervescence, in which …

Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics

RA Aogo, JV Zambrana, N Sanchez, S Ojeda… - Science translational …, 2023 - science.org
Sequential infection with multiple dengue virus (DENV) serotypes is thought to induce
enduring protection against dengue disease. However, long-term antibody waning has been …

Global spread and persistence of dengue

JL Kyle, E Harris - Annu. Rev. Microbiol., 2008 - annualreviews.org
Dengue is a spectrum of disease caused by four serotypes of the most prevalent arthropod-
borne virus affecting humans today, and its incidence has increased dramatically in the past …

Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease

SC Weaver, N Vasilakis - Infection, genetics and evolution, 2009 - Elsevier
Dengue viruses (DENV) are the most important arboviral pathogens in tropical and
subtropical regions throughout the world, putting at risk of infection nearly a third of the …