Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The incessant resistivity of pathogenic microbes to antibiotics continuously constitutes a
major threat to human wellness, thus, searching for effective therapeutic approaches …

Carbapenem resistance mediated by metallo-β-lactamases (MBL) such as New Delhi
metallo-β-lactamase-1 (NDM-1) has become a major factor threatening the efficacy of …

New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

β-Lactams have been a clinical focus since their emergence and indeed act as a powerful
tool to combat severe bacterial infections, but their effectiveness is threatened by drug …

The occurrence of resistances in Gram negative bacteria is steadily increasing to reach
extremely worrying levels and one of the main causes of resistance is the massive spread of …

The worldwide spread of the metallo-β-lactamases (MBL), especially New Delhi metallo-β-
lactamase-1 (NDM-1), is threatening the efficacy of β-lactams, which are the most potent and …

We use mass spectrometry (MS), under denaturing and non-denaturing solution conditions,
along with ultraviolet photodissociation (UVPD) to characterize structural variations in New …

The rise of life-threatening carbapenem-resistant Enterobacteriaceae (CRE) infections has
become a critical medical threat. Some of the most dangerous CRE bacteria can produce …

Objectives Bacterial strains that produce New Delhi metal-β-lactamase 1 (NDM-1) are a
worldwide health threat. It remains a challenging task to find a potent NDM-1 inhibitor for …