Significance of visual scene‐based learning in the hippocampal systems across mammalian species
The hippocampus and its associated cortical regions in the medial temporal lobe play
essential roles when animals form a cognitive map and use it to achieve their goals. As the …
essential roles when animals form a cognitive map and use it to achieve their goals. As the …
A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1
T Geiller, JB Priestley, A Losonczy - Current opinion in neurobiology, 2023 - Elsevier
The hippocampus is a multi-stage neural circuit that is critical for memory formation. Its
distinct anatomy has long inspired theories that rely on local interactions between neurons …
distinct anatomy has long inspired theories that rely on local interactions between neurons …
All-optical physiology resolves a synaptic basis for behavioral timescale plasticity
Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …
precise changes storing information in mammals have remained largely unclear. We …
Fos ensembles encode and shape stable spatial maps in the hippocampus
In the hippocampus, spatial maps are formed by place cells while contextual memories are
thought to be encoded as engrams,,,,–. Engrams are typically identified by expression of the …
thought to be encoded as engrams,,,,–. Engrams are typically identified by expression of the …
Associative and predictive hippocampal codes support memory-guided behaviors
Episodic memory involves learning and recalling associations between items and their
spatiotemporal context. Those memories can be further used to generate internal models of …
spatiotemporal context. Those memories can be further used to generate internal models of …
A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination
HC Ratigan, S Krishnan, S Smith… - Nature …, 2023 - nature.com
The adaptive regulation of fear memories is a crucial neural function that prevents
inappropriate fear expression. Fear memories can be acquired through contextual fear …
inappropriate fear expression. Fear memories can be acquired through contextual fear …
Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release
Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …
[HTML][HTML] Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences
Neurons in the hippocampus exhibit a striking selectivity for specific combinations of sensory
features, forming representations that are thought to subserve episodic memory. Even …
features, forming representations that are thought to subserve episodic memory. Even …
Hippocampal astrocytes encode reward location
Astrocytic calcium dynamics has been implicated in the encoding of sensory information,,,–,
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …
Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal
Hippocampal place cells support reward-related spatial memories by forming a cognitive
map that over-represents reward locations. The strength of these memories is modulated by …
map that over-represents reward locations. The strength of these memories is modulated by …