The hippocampus consists of a stereotyped neuronal circuit repeated along the septal- temporal axis. This transverse circuit contains distinct subfields with stereotyped connectivity …
The hippocampus plays a critical role in learning, memory, and spatial representation, processes that depend on the NMDA receptor (NMDAR). Inspired by recent findings that …
Environmental change may lead to new memories or modify old ones, but the underlying neural mechanisms are largely unclear. We recorded hippocampal place cells …
Hippocampal sharp wave/ripple oscillations are a prominent pattern of collective activity, which consists of a strong overall increase of activity with superimposed (140− 200 Hz) …
Hippocampal place cells exhibit spatially modulated firing, or place fields, which can remap to encode changes in the environment or other variables. Unique among hippocampal …
Hippocampal representations that underlie spatial memory undergo continuous refinement following formation. Here, to track the spatial tuning of neurons dynamically during offline …
Long-term potentiation (LTP) is regulated in part by metaplasticity, the activity-dependent alterations in neural state that coordinate the direction, amplitude, and persistence of future …
Hippocampal place cells are a well-known object in neuroscience, but their place field formation in the first moments of navigating in a novel environment remains an ill-defined …
CM Heer, EJ Mark - bioRxiv, 2023 - ncbi.nlm.nih.gov
Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic plasticity, shaping neuronal activity, and influencing learning and memory. Recently it has …