Signatures of rapid synaptic learning in the hippocampus during novel experiences

JB Priestley, JC Bowler, SV Rolotti, S Fusi, A Losonczy - bioRxiv, 2021 - biorxiv.org
Neurons in the hippocampus exhibit striking selectivity for specific combinations of sensory
features, forming representations which are thought to subserve episodic memory. Even …

Dissociating encoding of memory and salience by manipulating long-term synaptic potentiation

K Kaganovsky, MH Plitt, R Yang, R Sando… - bioRxiv, 2022 - biorxiv.org
Neural codes are thought to be reorganized during memory formation by long-term
potentiation (LTP) of synapses. Here, using a novel approach for selectively blocking LTP …

Multiple representations in geospatial databases, the brain's spatial cells, and deep learning algorithms

M Yuan - Cartography and Geographic Information Science, 2023 - Taylor & Francis
Buttenfield (1988) pioneered research on multiple representations in the dawn of GIScience.
Her efforts evoked inquiries into fundamental issues arising from the selective abstractions …

[HTML][HTML] Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval

HC Ratigan, S Krishnan, S Smith, MEJ Sheffield - bioRxiv, 2023 - ncbi.nlm.nih.gov
Memory retrieval of fearful experiences is essential for survival but can be maladaptive if not
appropriately suppressed. Fear memories can be acquired through contextual fear …

Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway

R Yang, N Hu, T Liu, Y Qu, J Liu, J Wang, B Yang, C Li - Phytomedicine, 2024 - Elsevier
Background Cerebral ischemia-reperfusion injury (CIRI) is a phenomenon that pathological
injury of ischemic brain tissue is further aggravated after the restoration of blood supply. The …

Network mechanisms underlying representational drift in area CA1 of hippocampus

F Devalle, A Roxin - bioRxiv, 2022 - biorxiv.org
Chronic imaging experiments in mice have revealed that the hippocampal code drifts over
long time scales. Specifically, the subset of cells which are active on any given session in a …

The role of astrocytes in place cell formation: A computational modeling study

I Polykretis, KP Michmizos - Journal of computational neuroscience, 2022 - Springer
Place cells develop spatially-tuned receptive fields during the early stages of novel
environment exploration. The generative mechanism underlying these spatially-selective …

Uncovering the Secrets of the Concept of Place in Cognitive Maps Aided by Artificial Intelligence

JA Fernandez-Leon, GG Acosta - Cognitive Computation, 2022 - Springer
Uncovering how mental representations acquire, recall, and decode spatial information
about relative locations and environmental attributes (cognitive map) involves different …

Astrocytes regulate spatial memory in a sex-specific manner

SM Meadows, F Palaguachi, A Licht-Murava, D Barnett… - bioRxiv, 2022 - biorxiv.org
Cognitive processes and neurocognitive disorders are regulated by astrocytes and have
prominent sex differences. However, the contribution of astrocytes to sex differences is not …

The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11. 2 microdeletion …

J Jiang, D Wang, Y Jiang, X Yang, R Sun, J Chang… - Microbiome, 2024 - Springer
Background Microdeletion of the human chromosomal region 16p11. 2 (16p11. 2+/-) is a
prevalent genetic factor associated with autism spectrum disorder (ASD) and other …