Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

Angiotensin II (AngII), as an octapeptide hormone normally ionized at physiological pH,
cannot cross cell membranes and thus, relies on, two (mainly) G protein-coupled receptor …

Primary aldosteronism, a common cause of severe hypertension, features constitutive
production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial …

Primary aldosteronism is the most common cause of secondary hypertension, most
frequently due to an aldosterone-producing adenoma or idiopathic hyperaldosteronism …

Objective Metabolic diseases are an increasing problem in our society with the brain-
metabolic axis as a master regulator of the human body for sustaining homeostasis under …

Angiotensin II (A-II) regulation of aldosterone secretion is initiated by inducing cell
membrane depolarization, thereby increasing intracellular calcium and activating the …

Regulators of G-protein signaling (RGS) proteins are GTPase-activating proteins (GAP) for
various Gα subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins …

Testosterone is known to mediate its effects by two different mechanisms of action. In the so-
called “classical” pathway testosterone binds to cytosolic androgen receptors (AR), which …

Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a
pro-androgen in mammalian physiology. Here we show that at a physiological concentration …

In mammals, aldosterone is produced in the zona glomerulosa (zG), the outermost layer of
the adrenal cortex, whereas glucocorticoids are produced in adjacent zona fasciculata (zF) …