Aging is a complex multidimensional, progressive remodeling process affecting multiple
organ systems. While many studies have focused on studying aging across multiple organs …

The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to
Substance P, and plays a role in acute stress reactions and pain transmission in mice. Here …

Epigenetic clocks based on DNA methylation have been known as biomarkers of aging,
including principal component (PC) clocks representing the degree of aging and …

Measures of epigenetic aging derived from DNA methylation (DNAm) have enabled the
assessment of biological aging in new populations and cohorts. In the present study, we …

Background Epigenetic ageing is among the most promising ageing biomarkers and may be
a useful marker of physical function decline, beyond chronological age. This study …

DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging
biomarkers linked to dementia risk. We investigated their relationship and combined …

It is imperative to study sex differences in brain morphology and function. However, there are
major observable and unobservable confounding factors that can contribute to the estimated …

HIV and its treatment may affect the growth and development of organ function and the
mental health of youth who are living with perinatally-acquired HIV (PHIV). Recent research …