[HTML][HTML] Alzheimer's Disease as A Viral Infectious Disease: Revisiting the Infectious Hypothesis

F Bruno, P Abondio, R Bruno, L Ceraudo… - Ageing research …, 2023 - Elsevier
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
Two major forms of the disease exist: sporadic-the causes of which have not yet been fully …

Management of oral herpes simplex virus infections: The problem of resistance. A narrative review

E Piperi, E Papadopoulou, M Georgaki, S Dovrat… - Oral …, 2024 - Wiley Online Library
Abstract Herpes Simplex Virus (HSV) type 1 (HSV‐1) and type 2 (HSV‐2) are among the
most common human viral pathogens, affecting several billion people worldwide. Although …

Neonatal herpes simplex virus infection: From the maternal infection to the child outcome

DU De Rose, S Bompard, C Maddaloni… - Journal of Medical …, 2023 - Wiley Online Library
This review examines the recent literature on the management of herpes simplex virus
(HSV) infections in neonates. We summarized the three clinical categories of maternal HSV …

[HTML][HTML] Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review

N Coppola, T Cantile, D Adamo, F Canfora… - Clinical Oral …, 2023 - Springer
Objectives Herpes simplex virus 1 (HSV-1) is the main pathogen responsible for herpes
infections. In 13–30% of the cases, primary HSV-1 leads to the primary herpetic …

[HTML][HTML] Optimizing antiviral dosing for HSV and CMV treatment in immunocompromised patients

DW Huntjens, JA Dijkstra, LN Verwiel, M Slijkhuis… - Pharmaceutics, 2023 - mdpi.com
Herpes simplex virus (HSV) and cytomegalovirus (CMV) are DNA viruses that are common
among humans. Severely immunocompromised patients are at increased risk of developing …

[HTML][HTML] Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers

M Wild, D Karner, J Eickhoff, S Wagner, J Kicuntod… - Pharmaceutics, 2023 - mdpi.com
Despite the availability of currently approved antiviral drugs, infections with human
cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening …

[HTML][HTML] Current perspectives on the management of herpesvirus infections in solid organ transplant recipients

SRK Malahe, JJA van Kampen, OC Manintveld… - Viruses, 2023 - mdpi.com
Solid organ transplant recipients (SOTRs) are at high risk of human herpesvirus (HHV)-
related morbidity and mortality due to the use of immunosuppressive therapy. We aim to …

Cell and tissue specific metabolism of nucleoside and nucleotide drugs: case studies and implications for precision medicine

EE To - Drug Metabolism and Disposition, 2023 - ASPET
Many clinically used antiviral drugs are nucleoside or nucleotide analog drugs, which have
a unique mechanism of action that requires intracellular phosphorylation. This dependence …

[HTML][HTML] Insights into antiviral properties and molecular mechanisms of non-flavonoid polyphenols against human herpesviruses

STS Hassan, M Šudomová, A Mazurakova… - International Journal of …, 2022 - mdpi.com
Herpesviruses are one of the most contagious DNA viruses that threaten human health,
causing severe diseases, including, but not limited to, certain types of cancer and …

[HTML][HTML] Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems

DS Karpov, NA Demidova, KA Kulagin… - International Journal of …, 2022 - mdpi.com
Almost all people become infected with herpes viruses, including herpes simplex virus type
1 (HSV-1), during their lifetime. Typically, these viruses persist in a latent form that is …