[HTML][HTML] Characterizing fitness and immune escape of SARS-CoV-2 EG. 5 sublineage using elderly serum and nasal organoid
X Zhang, SJA Lam, JD Ip, CHY Fong, AWH Chu… - Iscience, 2024 - cell.com
SARS-CoV-2 Omicron variant has evolved into sublineages. Here, we compared the
neutralization susceptibility and viral fitness of EG. 5.1 and XBB. 1.9. 1. Serum neutralization …
neutralization susceptibility and viral fitness of EG. 5.1 and XBB. 1.9. 1. Serum neutralization …
Eco-evolutionary dynamics of adapting pathogens and host immunity
P Barrat-Charlaix, RA Neher - arXiv preprint arXiv:2402.07252, 2024 - arxiv.org
As pathogens spread in a population of hosts, immunity is built up and the pool of
susceptible individuals is depleted. This generates selective pressure, to which many …
susceptible individuals is depleted. This generates selective pressure, to which many …
CovTransformer: A transformer model for SARS-CoV-2 lineage frequency forecasting
Y Feng, EE Goldberg, M Kupperman, X Zhang, Y Lin… - medRxiv, 2024 - medrxiv.org
With hundreds of SARS-CoV-2 lineages circulating in the global population, there is an
urgent need for forecasting lineage frequencies and thus identifying rapidly expanding …
urgent need for forecasting lineage frequencies and thus identifying rapidly expanding …
Variant-specific humoral immune response to SARS-CoV-2 escape mutants arising in clinically severe, prolonged infection
T Guenther, M Schoefbaenker, EU Lorentzen… - medRxiv, 2024 - medrxiv.org
Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of
protective immunity, though insufficient antibody responses may cause the emergence of …
protective immunity, though insufficient antibody responses may cause the emergence of …
Learning the fitness dynamics of pathogens from phylogenies
The dynamics of pathogen genetic diversity, including the emergence of lineages with
increased fitness, is a foundational concept of disease ecology with key public health …
increased fitness, is a foundational concept of disease ecology with key public health …
[HTML][HTML] Concepts and methods for predicting viral evolution
M Meijers, D Ruchnewitz, J Eberhardt, M Karmakar… - ArXiv, 2024 - ncbi.nlm.nih.gov
The seasonal human influenza virus undergoes rapid evolution, leading to significant
changes in circulating viral strains from year to year. These changes are typically driven by …
changes in circulating viral strains from year to year. These changes are typically driven by …
A unified theory for predicting pathogen mutual invasibility and co-circulation
A key aim in the dynamics and control of infectious diseases is predicting competitive
outcomes of pathogen interactions. Observed pathogen community structure indicates both …
outcomes of pathogen interactions. Observed pathogen community structure indicates both …
Broad-spectrum RNA prophylactic and therapeutic interventions for SARS-CoV-2
A Gontu - 2024 - etda.libraries.psu.edu
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the cause of
coronavirus disease-2019 (COVID-19) pandemic is undergoing continuous evolution …
coronavirus disease-2019 (COVID-19) pandemic is undergoing continuous evolution …