Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical
evidence has linked cell metabolism with cancer outcomes. Together, these observations …

Background Sinonasal neoplasms, whether benign and malignant, pose a significant
challenge to clinicians and represent a model area for multidisciplinary collaboration in …

A 44-year old woman with recurrent solitary fibrous tumor (SFT)/hemangiopericytoma was
enrolled in a clinical sequencing program including whole-exome and transcriptome …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Background The purpose of this study was to confirm sunitinib activity in alveolar soft part
sarcoma (ASPS) and to report on new insights into the molecular bases thereof. Patients …

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth
hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the …

Background To report on sunitinib activity in a retrospective series of 35 solitary fibrous
tumor (SFT) treated at a single institution. Patients and methods From April 2008, 35 patients …

Simple Summary In the latest WHO classification, solitary fibrous tumors (SFTs) are now
subdivided into benign SFT (intermediate category (locally aggressive)), SFT NOS …

Background Extra-pleural and extra-meningeal solitary fibrous tumour (SFT) is a rare
sarcoma histotype curable with surgery in the majority of patients. The behaviour of these …

Purpose: Preclinical models demonstrate synergistic antitumor activity with combination
blockade of mTOR and IGF-1R signaling. We aimed to determine the safety, tolerability, and …