Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents

R Lordan, A Tsoupras, I Zabetakis - Blood reviews, 2021 - Elsevier
Platelets are central to inflammation-related manifestations of cardiovascular diseases
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …

[HTML][HTML] Molecular insights into SARS COV-2 interaction with cardiovascular disease: role of RAAS and MAPK signaling

Z Wehbe, S Hammoud, N Soudani, H Zaraket… - Frontiers in …, 2020 - frontiersin.org
In December 2019, reports of viral pneumonia came out of Wuhan city in Hubei province in
China. In early 2020, the causative agent was identified as a novel coronavirus (CoV) …

[HTML][HTML] Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway

W Qin, J Li, R Zhu, S Gao, J Fan, M Xia… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
The pathophysiological mechanism of white matter hyperintensities of cerebral small vessel
disease (CSVD) includes an impaired blood-brain barrier (BBB) with increased permeability …

Systemic drugs with impact on osteoarthritis

D Apostu, O Lucaciu, A Mester… - Drug metabolism …, 2019 - Taylor & Francis
Articular cartilage has a complex structure and metabolism which allow for a proper
movement within joints. Nevertheless, several systemically administered pharmacological …

Aspirin enhances trophoblast invasion and represses soluble fms-like tyrosine kinase 1 production: a putative mechanism for preventing preeclampsia

MT Su, CY Wang, PY Tsai, TY Chen… - Journal of …, 2019 - journals.lww.com
Objective: Recent studies suggested that prophylactic aspirin prior to 16 weeks of gestation
in high-risk patients may reduce the risk of developing preeclampsia; however, the exact …

[HTML][HTML] Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of …

X Zhang, H Feng, J Du, J Sun, D Li… - International …, 2018 - spandidos-publications.com
Rheumatoid arthritis (RA) is a commonly occurring autoimmune disease. Its defining
pathological characteristic is the excessive proliferation of fibroblast‑like synoviocytes (FLS) …

Nonsteroidal anti-inflammatory drugs: a potential pharmacological treatment for intracranial aneurysm

CL Fisher, SL Demel - Cerebrovascular diseases extra, 2019 - karger.com
Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of
intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated …

[HTML][HTML] Stearoyl-CoA desaturase regulates angiogenesis and energy metabolism in ischemic cardiomyocytes

AM Gan, Z Tracz-Gaszewska… - International Journal of …, 2022 - mdpi.com
New blood vessel formation is a key component of the cardiac repair process after
myocardial infarction (MI). Hypoxia following MI is a major driver of angiogenesis in the …

Up-regulation of CKAP2L expression promotes lung adenocarcinoma invasion and is associated with poor prognosis

G Xiong, L Li, X Chen, S Song, Y Zhao… - OncoTargets and …, 2019 - Taylor & Francis
Aim The purpose of this study is to consider the function of cytoskeleton-associated protein 2-
like (CKAP2L) in lung adenocarcinoma (LAD) development and its prognostic value …

Suppression of lipopolysaccharide-induced activation of RAW 264.7 macrophages by Se-methylseleno-l-cysteine

G Wang, Q Zhan, H Wu - International Immunopharmacology, 2020 - Elsevier
Abstract Se-methylseleno-l-cysteine (l-SeMC) is a natural source of organic selenium for
humans. Although it has a structure similar to that of l-Cysteine (l-Cys), its anti-inflammatory …