Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes
among mucosa, which plays an indispensable role in the first-line protection against …

Background Sepsis is a major cause of mortality and morbidity globally, with around one-
quarter of all sepsis-related deaths occurring in children under the age of 5. We conducted a …

Redesigning protein-protein interfaces is an important tool for developing therapeutic
strategies. Interfaces can be redesigned by in silico screening, which allows for efficient …

The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases
with the bloodstream. Given their perpetual exposure to external particulates and …

Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in
cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal …

The SARS-COV-2 virus is a deadly agent of inflammatory respiratory disease. Since 2020,
studies have focused on developing new therapies based on galactose-rich IgA antibodies …

Mucosal immunity has regained its spotlight amidst the ongoing Coronavirus Disease 19
(COVID-19) pandemic, with numerous studies highlighting the crucial role of mucosal …

Immunoglobulin A (IgA) is the most abundant antibody (Ab) in human mucosae, with
secretory form (sIgA) being dominant and uniquely stable. sIgA is challenging to produce …

Intravenous immunoglobulin (IVIG) has been developed for over 40 years. The mechanisms
of action of IVIG are complex and diverse, and there may be multiple mechanisms that …

Inborn errors of immunity (IEI) are multifaced diseases which can present with a variety of
phenotypes, ranging from infections to autoimmunity, lymphoproliferation, and neoplasms. In …