Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease

JC Lambert, A Ramirez, B Grenier-Boley… - Molecular …, 2023 - nature.com
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager‐horticulturalists

M Gatz, WJ Mack, HC Chui, EM Law… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We evaluated the prevalence of dementia and mild cognitive impairment (MCI)
in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods Participants …

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics

TF Chan, X Rui, DV Conti, M Fornage, M Graff… - The American Journal of …, 2023 - cell.com
The heritability explained by local ancestry markers in an admixed population (h γ 2)
provides crucial insight into the genetic architecture of a complex disease or trait. Estimation …

Genome-wide admixture mapping identifies wild ancestry-of-origin segments in cultivated Robusta coffee

T Vi, Y Vigouroux, P Cubry, P Marraccini… - Genome Biology and …, 2023 - academic.oup.com
Humans have had a major influence on the dissemination of crops beyond their native
range, thereby offering new hybridization opportunities. Characterizing admixed genomes …

Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35

S Cullina, GL Wojcik, R Shemirani, D Klarin… - Frontiers in …, 2023 - frontiersin.org
Peripheral artery disease (PAD) is a form of atherosclerotic cardiovascular disease,
affecting∼ 8 million Americans, and is known to have racial and ethnic disparities. PAD has …

Gallbladder cancer risk and indigenous South American Mapuche ancestry: instrumental variable analysis using ancestry-informative markers

L Zollner, F Boekstegers, C Barahona Ponce… - Cancers, 2023 - mdpi.com
Simple Summary An association between individual levels of indigenous Chilean Mapuche
ancestry and the risk of gallbladder cancer has been reported in observational studies, and …

Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers

L Zollner, D Torres, I Briceno, M Gilbert… - Breast Cancer …, 2023 - Springer
Abstract Background Latin American and Hispanic women are less likely to develop breast
cancer (BC) than women of European descent. Observational studies have found an inverse …

Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

E Herrera-Luis, ACY Mak, J Perez-Garcia… - Thorax, 2023 - thorax.bmj.com
Background In the USA, genetically admixed populations have the highest asthma
prevalence and severe asthma exacerbations rates. This could be explained not only by …

The power of representation: Statistical analysis of diversity in US Alzheimer's disease genetics data

D Xue, EE Blue, MP Conomos… - Alzheimer's & Dementia …, 2024 - Wiley Online Library
INTRODUCTION Alzheimer's disease (AD) is a complex disease influenced by genetics and
environment. More than 75 susceptibility loci have been linked to late‐onset AD, but most of …

[PDF][PDF] Admixture mapping implicates 13q33. 3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations

ARVR Horimoto, LA Boyken, EE Blue, KE Grinde… - Human Genetics and …, 2023 - cell.com
Alzheimer disease (AD) is the most common form of senile dementia, with high incidence
late in life in many populations including Caribbean Hispanic (CH) populations. Such …