Tissue-resident macrophages have pivotal functions for tissue defense and homeostasis.
Two main discoveries have changed our current understanding of macrophage …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and
escape from immunity via T cell suppression. Initially, these myeloid cells were identified as …

Defining the metabolic programs that underlie stem cell maintenance will be essential for
developing strategies to manipulate stem cell capacity. Mammalian hematopoietic stem cells …

Cancer stem cells (CSCs) are a distinct population of cells within tumors with capabilities of
self-renewal and tumorigenicity. CSCs play a pivotal role in cancer progression, metastasis …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated
process that requires constant replenishment. All mature blood cells are generated from …

Stem cells have the unique capacity to differentiate into many cell types during embryonic
development and postnatal growth. Through coordinated cellular behaviors (self‐renewal …