[HTML][HTML] All hands on deck: SARS-CoV-2 proteins that block early anti-viral interferon responses

AC Setaro, MM Gaglia - Current research in virological science, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is responsible for
the current pandemic coronavirus disease of 2019 (COVID-19). Like other pathogens, SARS …

A comprehensive evolutionary and epidemiological characterization of insertion and deletion mutations in SARS-CoV-2 genomes

X Liu, L Guo, T Xu, X Lu, M Ma, W Sheng, Y Wu… - Virus …, 2021 - academic.oup.com
Abstract SARS-CoV-2, which causes the current pandemic of respiratory illness, is evolving
continuously and generating new variants. Nevertheless, most of the sequence analyses …

Transmission cluster of COVID-19 cases from Uruguay: emergence and spreading of a novel SARS-CoV-2 ORF6 deletion

Y Panzera, N Ramos, L Calleros… - Memórias do Instituto …, 2022 - SciELO Brasil
BACKGROUND Evolutionary changes in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) include indels in non-structural, structural, and accessory open reading …

SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport

T Makio, K Zhang, N Love, FD Mast, X Liu… - Molecular biology of …, 2024 - Am Soc Cell Biol
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) accessory protein
Orf6 works as an interferon antagonist, in part, by inhibiting the nuclear import activated p …

Identifying featured indels associated with SARS-CoV-2 fitness

X Li, H Yan, G Wong, W Ouyang, J Cui - Microbiology Spectrum, 2023 - Am Soc Microbiol
As an RNA virus, severe acute respiratory coronavirus 2 (SARS-CoV-2) is known for
frequent substitution mutations, and substitutions in important genome regions are often …

[HTML][HTML] Insertions in SARS-CoV-2 genome caused by template switch and duplications give rise to new variants that merit monitoring

SK Garushyants, IB Rogozin, EV Koonin - BioRxiv, 2021 - ncbi.nlm.nih.gov
The appearance of multiple new SARS-CoV-2 variants during the winter of 2020–2021 is a
matter of grave concern. Some of these new variants, such as B. 1.617. 2, B. 1.1. 7, and B …

[HTML][HTML] Therapeutic potential of natural alkaloid emetine against emerging COVID-19 and future viral pandemics

B Dinda, S Dinda, M Dinda, IS Sarma… - European Journal of …, 2024 - Elsevier
The outbreak of COVID-19 pandemic caused by the infection of SARS-CoV-2, has become a
global crisis, threatening public health and disrupting global economy. Until now, effective …

SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction

O Khatun, M Sharma, R Narayan, S Tripathi - Cellular and Molecular Life …, 2023 - Springer
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide
replication advantage to the virus and contribute to COVID-19 pathogenesis. We explored …

NASCarD (Nanopore Adaptive Sampling with Carrier DNA): A rapid, PCR-free method for SARS-CoV-2 whole-genome sequencing in clinical samples

MA Terrazos Miani, L Borcard, S Gempeler… - Pathogens, 2024 - mdpi.com
Whole-genome sequencing (WGS) represents the main technology for SARS-CoV-2 lineage
characterization in diagnostic laboratories worldwide. The rapid, near-full-length sequencing …

Challenges of SARS-CoV-2 genomic surveillance in India during low positivity rate scenario

SS Tomar, K Khairnar - Frontiers in Public Health, 2023 - frontiersin.org
Being the second most populous country in the world, India presents valuable lessons for
the world about dealing with the SARS-CoV-2 pandemic. From this perspective, we …