Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Distinct regions harboring cancer stem cells (CSCs) have been identified within the
microenvironment of various tumors, and as in the case of their healthy counterparts, these …

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

The dependency of cancer cells on glutamine may be exploited therapeutically as a new
strategy for treating cancers that lack druggable driver genes. Here we found that human …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Polydopamine (PDA) has attracted much attention recently due to its strong adhesion
capability to most substrates. After combining with organic (such as organic metal …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often
causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded …

Background Kaempferol is extracted from Hedyotis diffusa, exerting an obvious anti-cancer
effect. Here in the present study, we explored the anti-cancer effects and mechanism of …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …