[HTML][HTML] Cross-disorder genomics data analysis elucidates a shared genetic basis between major depression and osteoarthritis pain
Osteoarthritis (OA) and major depression (MD) are two debilitating disorders that frequently
co-occur and affect millions of the elderly each year. Despite the greater symptom severity …
co-occur and affect millions of the elderly each year. Despite the greater symptom severity …
[HTML][HTML] Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study
Risperidone is routinely used in the clinical management of schizophrenia, but the treatment
response is highly variable among different patients. The genetic underpinnings of the …
response is highly variable among different patients. The genetic underpinnings of the …
[HTML][HTML] Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology
Cognitive deficits are known to be related to most forms of psychopathology. Here, we
perform local genetic correlation analysis as a means of identifying independent segments …
perform local genetic correlation analysis as a means of identifying independent segments …
[HTML][HTML] Genome-wide association study of motor coordination
The ability to finely control our movement is key to achieving many of the educational
milestones and life-skills we develop throughout our lives. Despite the centrality of …
milestones and life-skills we develop throughout our lives. Despite the centrality of …
[HTML][HTML] Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis
Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …
Although cognitive deficits are one of the factors most strongly associated with functional …
[HTML][HTML] Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy
Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and
decreased life expectancy, yet common predisposing variation substantially contributes to …
decreased life expectancy, yet common predisposing variation substantially contributes to …
[HTML][HTML] Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort
Cannabis use is of increasing public health interest globally. Here we examined the effect of
heavy cannabis use, with and without tobacco, on genome-wide DNA methylation in a …
heavy cannabis use, with and without tobacco, on genome-wide DNA methylation in a …
[HTML][HTML] Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community
CC Soo, JT Brandenburg, A Nebel, S Tollman… - Communications …, 2023 - nature.com
Cognitive function is an indicator for global physical and mental health, and cognitive
impairment has been associated with poorer life outcomes and earlier mortality. A standard …
impairment has been associated with poorer life outcomes and earlier mortality. A standard …
[HTML][HTML] Involvement of the long intergenic non-coding RNA LINC00461 in schizophrenia
S Rao, L Tian, H Cao, A Baranova, F Zhang - BMC psychiatry, 2022 - Springer
Objective LINC00461 is a highly conserved intergenic non-protein coding RNA that was
implicated in schizophrenia at the genome-wide level. We aim to explore potential …
implicated in schizophrenia at the genome-wide level. We aim to explore potential …
[HTML][HTML] Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan
L Vilar-Ribó, J Cabana-Domínguez… - …, 2023 - nature.com
There is evidence linking ADHD to a reduced life expectancy. The mortality rate in
individuals with ADHD is twice that of the general population and it is associated with …
individuals with ADHD is twice that of the general population and it is associated with …