ASCL1 Is Involved in the Pathogenesis of Schizophrenia by Regulation of Genes Related to Cell Proliferation, Neuronal Signature Formation, and Neuroplasticity

DA Abashkin, DS Karpov, AO Kurishev… - International Journal of …, 2023 - mdpi.com
Schizophrenia (SZ) is a common psychiatric neurodevelopmental disorder with a complex
genetic architecture. Genome-wide association studies indicate the involvement of several …

A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia

A Levchenko, A Kanapin, A Samsonova… - Progress in Neuro …, 2021 - Elsevier
In the present study we conducted a genome-wide association study (GWAS) in a cohort of
505 patients with paranoid schizophrenia (SCZ), of which 95 had tardive dyskinesia (TD) …

Analysis of whole exome sequencing in severe mental illness hints at selection of brain development and immune related genes

J Mahadevan, AK Pathak, A Vemula, RK Nadella… - Scientific Reports, 2021 - nature.com
Evolutionary trends may underlie some aspects of the risk for common, non-communicable
disorders, including psychiatric disease. We analyzed whole exome sequencing data from …

[HTML][HTML] The shared genetic architecture of suicidal behaviour and psychiatric disorders: A genomic structural equation modelling study

T Kootbodien, L London, LJ Martin, J Defo… - Frontiers in …, 2023 - frontiersin.org
Background: Suicidal behaviour (SB) refers to behaviours, ranging from non-fatal suicidal
behaviour, such as suicidal ideation and attempt, to completed suicide. Despite recent …

[PDF][PDF] SATB2 organizes the 3D genome architecture of cognition in cortical neurons

N Wahl, S Espeso-Gil, P Chietera, A Nagel… - Molecular Cell, 2024 - cell.com
The DNA-binding protein SATB2 is genetically linked to human intelligence. We studied its
influence on the three-dimensional (3D) epigenome by mapping chromatin interactions and …

Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study

MC Barbu, M Harris, X Shen, S Aleks, C Green… - Epigenetics, 2022 - Taylor & Francis
ABSTRACT A complex interplay of genetic and environmental risk factors influence global
brain structural alterations associated with brain health and disease. Epigenome-wide …

Polygenic contributions to performance on the Balloon Analogue Risk Task

EL Nurmi, CP Laughlin, H de Wit, AA Palmer… - Molecular …, 2023 - nature.com
Risky decision-making is a common, heritable endophenotype seen across many
psychiatric disorders. Its underlying genetic architecture is incompletely explored. We …

Age-dependent patterns of schizophrenia genetic risk affect cognition

SS Kuo, CW Musket, PE Rupert, L Almasy, RC Gur… - Schizophrenia …, 2022 - Elsevier
Cognition shares substantial genetic overlap with schizophrenia, yet it remains unclear
whether such genetic effects become significant during developmental periods of elevated …

Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis

A Djordjevic, M Zivkovic, I Koncar, A Stankovic… - Journal of Stroke and …, 2022 - Elsevier
Objectives Galectin-3 affects a variety of biological processes. It is encoded by LGALS-3,
located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 …

The genetic architecture of cerebellar lobules: insights from the uk biobank

A Carriόn-Castillo, C Boeckx - bioRxiv, 2022 - biorxiv.org
In this work we take advantage of opportunities afforded by the UK Biobank, and
complement recent studies examining the genetics of cerebellar volume from that vantage …