Extracellular matrix assembly: a multiscale deconstruction

JK Mouw, G Ou, VM Weaver - Nature reviews Molecular cell biology, 2014 - nature.com
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-
specific cell behaviour. The molecules that are associated with the ECM of each tissue …

[HTML][HTML] Epithelial barrier dysfunction in chronic respiratory diseases

FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

[HTML][HTML] Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells

H Wu, Y Yu, H Huang, Y Hu, S Fu, Z Wang, M Shi… - Cell, 2020 - cell.com
Fibrosis can develop in most organs and causes organ failure. The most common type of
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …

[HTML][HTML] Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis

Y Xu, T Mizuno, A Sridharan, Y Du, M Guo, J Tang… - JCI insight, 2016 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …

[HTML][HTML] Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement

Y Li, T Shi, X Li, H Sun, X Xia, X Ji, J Zhang, M Liu… - Environment …, 2022 - Elsevier
Tire wear microplastic particles (TWMPs) are emerging microplastic pollutants that have
gained increasing attention lately. However, the health effect of inhaled airborne TWMPs …

[HTML][HTML] Targeting histone deacetylases in idiopathic pulmonary fibrosis: a future therapeutic option

M Korfei, P Mahavadi, A Guenther - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Regional and disease specific human lung extracellular matrix composition

ET Hoffman, FE Uhl, L Asarian, B Deng, C Becker… - Biomaterials, 2023 - Elsevier
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and
idiopathic pulmonary fibrosis (IPF), are characterized by regional extracellular matrix (ECM) …

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

AE John, C Joseph, G Jenkins… - Immunological reviews, 2021 - Wiley Online Library
The COVID‐19 pandemic rapidly spread around the world following the first reports in
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …

[HTML][HTML] IL-33 mediated inflammation in chronic respiratory diseases—understanding the role of the member of IL-1 superfamily

A Gabryelska, P Kuna, A Antczak… - Frontiers in …, 2019 - frontiersin.org
Interleukin 33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 is localized in the
nucleus and acts there as a gene regulator. Following injury, stress or cell death, it is …

[HTML][HTML] The role of mesenchymal stem cells in radiation-induced lung fibrosis

M Zanoni, M Cortesi, A Zamagni, A Tesei - International journal of …, 2019 - mdpi.com
Radiation therapy is one of the most important treatment modalities for thoracic tumors.
Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still …