Ca2+ currents in cardiomyocytes: How to improve interpretation of patch clamp data?

D Ismaili, B Geelhoed, T Christ - Progress in biophysics and molecular …, 2020 - Elsevier
Objectives Variability of ion currents is major issue when used for significance testing. One
of the simplest approach to reduce variability is normalization to cell membrane size …

Extra-aortic balloon counterpulsation: an intraoperative feasibility study

ME Legget, WS Peters, FP Milsom, JS Clark, TM West… - Circulation, 2005 - Am Heart Assoc
Background—Current methods of counterpulsation or ventricular assistance have significant
vascular and limb complications. The aim of this study was to determine the safety and …

Left ventricular assist device-induced molecular changes in the failing myocardium

GKR Soppa, PJR Barton… - Current opinion in …, 2008 - journals.lww.com
Left ventricular assist device-induced molecular changes in... : Current Opinion in Cardiology
Left ventricular assist device-induced molecular changes in the failing myocardium : Current …

β2-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic …

S Xydas, AR Kherani, JS Chang, S Klotz, I Hay… - … of Pharmacology and …, 2006 - ASPET
The benefit of the β2-adrenergic agonist, clenbuterol, in left ventricular assist device patients
with dilated cardiomyopathy has been reported, but its effect on ischemic heart failure (HF) is …

Heterotopic abdominal rat heart transplantation as a model to investigate volume dependency of myocardial remodeling

K Benke, AA Sayour, C Mátyás, B Ágg… - …, 2017 - journals.lww.com
Heterotopic abdominal rat heart transplantation has been extensively used to investigate
ischemic-reperfusion injury, immunological consequences during heart transplantations and …

Management of ventricular arrhythmias in patients with ventricular assist devices

DM Pedrotty, JE Rame… - Current Opinion in …, 2013 - journals.lww.com
As the application of long-term VAD support continues to grow, it will be increasingly
important to clarify and target the mechanisms contributing to ventricular arrhythmias in this …

Ventricular assist device therapy

G Sayer, Y Naka, UP Jorde - Cardiovascular therapeutics, 2009 - Wiley Online Library
Ventricular assist devices are an important therapeutic option for advanced congestive heart
failure. A left ventricular assist device (LVAD) can be implanted as a bridge to …

Cellular and Molecular Mechanisms Activated by a Left Ventricular Assist Device

A Galeone, C Buccoliero, B Barile, GP Nicchia… - International Journal of …, 2023 - mdpi.com
Left ventricular assist devices (LVADs) represent the final treatment for patients with end-
stage heart failure (HF) not eligible for transplantation. Although LVAD design has been …

Novel targets for a combination of mechanical unloading with pharmacotherapy in advanced heart failure

A Jedrzejewska, A Braczko, A Kawecka… - International Journal of …, 2022 - mdpi.com
LVAD therapy is an effective rescue in acute and especially chronic cardiac failure. In
several scenarios, it provides a platform for regeneration and sustained myocardial …

Molecular changes occurring during reverse remodelling following left ventricular assist device support

EJ Birks, RS George - Journal of cardiovascular translational research, 2010 - Springer
Remodelling is the central feature that occurs in the progression of heart failure. However,
unloading of the heart with a left ventricular assist device (LVAD) can lead to reversal of …