[HTML][HTML] Challenges and opportunities in modelling wet granulation in pharmaceutical industry–a critical review

M Singh, S Shirazian, V Ranade, GM Walker… - Powder Technology, 2022 - Elsevier
Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

[HTML][HTML] Challenges and opportunities concerning numerical solutions for population balances: a critical review

M Singh, V Ranade, O Shardt… - Journal of Physics A …, 2022 - iopscience.iop.org
Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

Accurate and efficient approximations for generalized population balances incorporating coagulation and fragmentation

M Singh - Journal of Computational Physics, 2021 - Elsevier
This study focuses on development of two approaches based on finite volume schemes for
solving both one-dimensional and multidimensional nonlinear simultaneous coagulation …

[HTML][HTML] Diastereomer salt crystallization: Comprehensive process modeling and DoE-driven comparison of custom-coded and user-friendly simulators

Á Orosz, MH Bosits, É Pusztai, H Pataki… - Chemical Engineering …, 2023 - Elsevier
Process modeling is gaining attention in the pharmaceutical industry due to the promise of
exploring the design space with less experimentation. However, the associated numerical …

Discrete finite volume approach for multidimensional agglomeration population balance equation on unstructured grid

M Singh, R Singh, S Singh, G Walker, T Matsoukas - Powder Technology, 2020 - Elsevier
In this work, a discrete finite volume scheme (FVS) is developed for approximating a
multidimensional agglomeration population balance equation on an unstructured grid …

[HTML][HTML] Modified variational iteration method and its convergence analysis for solving nonlinear aggregation population balance equation

S Yadav, M Singh, S Singh, S Heinrich, J Kumar - Computers & Fluids, 2024 - Elsevier
This study proposes a novel approach based on the variational iteration method to solve the
nonlinear aggregation population balance equation. The approach provides great flexibility …

New finite volume approach for multidimensional Smoluchowski equation on nonuniform grids

M Singh - Studies in Applied Mathematics, 2021 - Wiley Online Library
This present work is based on developing a deterministic discrete formulation for the
approximation of a multidimensional Smoluchowski (Coalescence) equation on a …

[HTML][HTML] Characterization of simultaneous evolution of size and composition distributions using generalized aggregation population balance equation

M Singh, A Kumar, S Shirazian, V Ranade, G Walker - Pharmaceutics, 2020 - mdpi.com
The application of multi-dimensional population balance equations (PBEs) for the simulation
of granulation processes is recommended due to the multi-component system. Irrespective …

[HTML][HTML] New discrete formulation for reduced population balance equation: an illustration to crystallization

M Singh, G Walker - Pharmaceutical Research, 2022 - Springer
In this paper, we focus on providing a discrete formulation for a reduced aggregation
population balance equation. The new formulation is simpler, easier to code, and adaptable …

Two moments consistent discrete formulation for binary breakage population balance equation and its convergence

M Singh, T Matsoukas, G Walker - Applied Numerical Mathematics, 2021 - Elsevier
A numerical scheme based on the finite volume approach is developed to solve a binary
breakage population balance equation (PBE) on nonuniform meshes. The key feature of the …