Exosomes: biomarkers and therapeutic targets of diabetic vascular complications

A Chen, H Wang, Y Su, C Zhang, Y Qiu… - Frontiers in …, 2021 - frontiersin.org
Diabetic vascular complications (DVC) including macrovascular and microvascular lesions,
have a significant impact on public health, and lead to increased patient mortality …

Multifaceted roles of extracellular RNAs in different diseases

AM Sohail, MB Khawar, A Afzal, A Hassan… - Military Medical …, 2022 - Springer
Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in
various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make …

[HTML][HTML] Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway

L Han, S Wang, J Li, L Zhao, H Zhou - Experimental and Molecular …, 2023 - Elsevier
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early
diagnostic and specific therapeutic approaches. Podocyte apoptosis and loss play important …

Coronavirus disease (COVID)-19 and diabetic kidney disease

SP Srivastava, R Srivastava, S Chand, JE Goodwin - Pharmaceuticals, 2021 - mdpi.com
The present review describes COVID-19 severity in diabetes and diabetic kidney disease.
We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and …

Research progress of extracellular vesicles in type 2 diabetes and its complications

M Zhang, L Wang, Z Chen - Diabetic Medicine, 2022 - Wiley Online Library
Type 2 diabetes is one of the most common chronic diseases in modern society. However,
there is still insufficient research on the pathogenesis, diagnosis and treatment of type 2 …

A circulating exosomal microRNA panel as a novel biomarker for monitoring post‐transplant renal graft function

Y Chen, X Han, Y Sun, X He… - Journal of Cellular and …, 2020 - Wiley Online Library
Accurate and effective biomarkers for continuous monitoring of graft function are needed
after kidney transplantation. The aim of this study was to establish a circulating exosomal …

Upregulation of miR145 and miR126 in EVs from renal cells undergoing EMT and urine of diabetic nephropathy patients

V Dimuccio, L Bellucci, M Genta, C Grange… - International Journal of …, 2022 - mdpi.com
Simple Summary Diabetic nephropathy is one of the most frequent complications of
diabetes, resulting from diffuse damage to different kidney cells. The identification of …

Effect of diabetes on exosomal miRNA profile in patients with obesity

H Kim, YU Bae, H Lee, H Kim, JS Jeon… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular
disease. T2DM increases the risk of cardiovascular-related death. We investigated changes …

Exosomes as biomarkers and therapy in type 2 diabetes mellitus and associated complications

N Satyadev, MI Rivera, NK Nikolov… - Frontiers in …, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic disorders worldwide.
However, T2DM still remains underdiagnosed and undertreated resulting in poor quality of …

Urinary-derived extracellular vesicles reveal a distinct microRNA signature associated with the development and progression of Fabry nephropathy

T Levstek, B Vujkovac, A Cokan Vujkovac… - Frontiers in …, 2023 - frontiersin.org
Introduction Early initiation is essential for successful treatment of Fabry disease, but
sensitive and noninvasive biomarkers of Fabry nephropathy are lacking. Urinary …