Capturing the Kidney Transcriptome by Urinary Extracellular Vesicles—From Pre-Analytical Obstacles to Biomarker Research

K Barreiro, OP Dwivedi, A Rannikko, H Holthöfer… - Genes, 2023 - mdpi.com
Urinary extracellular vesicles (uEV) hold non-invasive RNA biomarkers for genitourinary
tract diseases. However, missing knowledge about reference genes and effects of …

Extracellular vesicles: illuminating renal pathophysiology and therapeutic frontiers

L Shi, H Zeng, Z An, W Chen, Y Shan, C Ji… - European Journal of …, 2024 - Elsevier
Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu,
harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a …

Urinary extracellular vesicles and their miRNA cargo in patients with Fabry nephropathy

T Levstek, T Mlinšek, M Holcar, K Goričar, M Lenassi… - Genes, 2021 - mdpi.com
Current biomarkers of Fabry nephropathy lack sensitivity in detecting early kidney damage
and do not predict progression of nephropathy. Urinary extracellular vesicles (uEVs) and …

Profile of urinary exosomal microRNAs and their contribution to diabetic kidney disease through a predictive classification model

AK González‐Palomo, FJ Pérez‐Vázquez… - …, 2022 - Wiley Online Library
Aim Evaluate the expression of exomiRs‐126,‐146, and‐155 in urinary exosomes of
patients with T2DM and diabetic kidney disease to establish a predictive classification model …

Future embracing: exosomes driving a revolutionary approach to the diagnosis and treatment of idiopathic membranous nephropathy

L Wang, J Wang, A Xu, L Wei, M Pei, T Shen… - Journal of …, 2024 - Springer
Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults and is
associated with high rates of end-stage renal disease. Early detection and precise …

miR-30b-5p modulate renal epithelial-mesenchymal transition in diabetic nephropathy by directly targeting SNAI1

Y Wang, Y Liu, L Zhang, L Bai, S Chen, H Wu… - Biochemical and …, 2021 - Elsevier
Object Renal tubulointerstitial fibrosis plays a significant role in the development of diabetic
nephropathy (DN). SNAI1 is a main activator of epithelial-to-mesenchymal transition (EMT) …

MicroRNA‐126 in dogs with immune complex‐mediated glomerulonephritis

AD Cherry, CP Chu, RE Cianciolo… - Journal of Veterinary …, 2024 - Wiley Online Library
Background Most proteinuric dogs with naturally occurring chronic kidney disease have
amyloidosis (AMYL), glomerulosclerosis (GS), or immune complex‐mediated …

Extracellular vesicles in kidney diseases: moving forward

U Erdbrügger, EJ Hoorn, TH Le, CJ Blijdorp… - Kidney360, 2023 - journals.lww.com
Extracellular vesicles (EVs) are evolving as novel cell mediators, biomarkers, and
therapeutic targets in kidney health and disease. They are naturally derived from cells both …

The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics

J Kim, M Kim, JY Kang, KW Bong, N Choi - BioChip Journal, 2023 - Springer
Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of
biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal …

Association between Circulating MicroRNAs (miR-21-5p, miR-20a-5p, miR-29b-3p, miR-126-3p and miR-101-3p) and Chronic Allograft Dysfunction in Renal …

YJ Chen, CT Hsu, SF Tsai, CH Chen - International Journal of Molecular …, 2022 - mdpi.com
Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft
survival. Serum microRNA (miRNA) has been reported as a biomarker for various conditions …