Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

The COVID-19 pandemic has imposed extraordinary and unpredictable changes on our
lifestyle for an unknown duration. Consequently, core aspects of wellbeing including …

Chronotype can be defined as an expression or proxy for circadian rhythms of varied
mechanisms, for example in body temperature, cortisol secretion, cognitive functions, eating …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

False negative tests for SARS-CoV-2 are common and have important public health and
medical implications. We tested the hypothesis of diurnal variation in viral shedding by …

In mammals, physiology and metabolism are shaped both by immediate and anticipatory
responses to environmental changes through the myriad of molecular mechanisms. Whilst …

Timing is everything. Many organisms across the tree of life have evolved timekeeping
mechanisms that regulate numerous of their cellular functions to optimize timing by …

Various aspects of our physiology and immune response to pathogens are under 24 h
circadian control and its role in clinical and research practice is becoming increasingly …

Mechanical ventilation induces a number of systemic responses for which the brain plays an
essential role. During the last decade, substantial evidence has emerged showing that the …

Objective: Both critical illness and current care have been hypothesized to upset daily
rhythms and impair molecular circadian function. However, the influence of critical illness on …