Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …

The gut microbiome influences many host physiologies, spanning gastrointestinal function,
metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on …