Evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19: a cohort study

KE Kip, EK McCreary, K Collins, TE Minnier… - Annals of Internal …, 2023 - acpjournals.org
Background: Treatment guidelines and US Food and Drug Administration emergency use
authorizations (EUAs) of monoclonal antibodies (mAbs) for treatment of high-risk outpatients …

[HTML][HTML] COVID-19: systemic pathology and its implications for therapy

Q Shen, J Li, Z Zhang, S Guo, Q Wang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Responding to the coronavirus disease 2019 (COVID-19) pandemic has been an
unexpected and unprecedented global challenge for humanity in this century. During this …

The impact of neutralizing monoclonal antibodies on the outcomes of COVID‐19 outpatients: a systematic review and meta‐analysis of randomized controlled trials

WT Lin, SH Hung, CC Lai, CY Wang… - Journal of medical …, 2022 - Wiley Online Library
To assess the clinical efficacy and safety of neutralizing monoclonal antibodies (mABs) for
outpatients with coronavirus disease 2019 (COVID‐19). PubMed, Embase, Web of Science …

[HTML][HTML] Outcomes with and without outpatient SARS-CoV-2 treatment for patients with COVID-19 and systemic autoimmune rheumatic diseases: a retrospective …

G Qian, X Wang, NJ Patel, Y Kawano, X Fu… - The Lancet …, 2023 - thelancet.com
Background Some patients with systemic autoimmune rheumatic disease and
immunosuppression might still be at risk of severe COVID-19. The effect of outpatient SARS …

Engineering ACE2 decoy receptors to combat viral escapability

T Arimori, N Ikemura, T Okamoto, J Takagi… - Trends in …, 2022 - cell.com
Decoy receptor proteins that trick viruses to bind to them should be resistant to viral escape
because viruses that require entry receptors cannot help but bind decoy receptors …

Protective neutralizing epitopes in SARS‐CoV‐2

H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …

[HTML][HTML] A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

W Tai, K Yang, Y Liu, R Li, S Feng, B Chai… - Nature …, 2023 - nature.com
The respiratory system, especially the lung, is the key site of pathological injury induced by
SARS-CoV-2 infection. Given the low feasibility of targeted delivery of antibodies into the …

Neutralizing monoclonal antibody use and COVID-19 infection outcomes

N Ambrose, A Amin, B Anderson… - JAMA Network …, 2023 - jamanetwork.com
Importance Evidence on the effectiveness and safety of COVID-19 therapies across a
diverse population with varied risk factors is needed to inform clinical practice. Objective To …

[HTML][HTML] Chest CT severity score and systemic inflammatory biomarkers as predictors of the need for invasive mechanical ventilation and of covid-19 patients' mortality

I Halmaciu, EM Arbănași, R Kaller, AV Mureșan… - Diagnostics, 2022 - mdpi.com
Background: Numerous tools, including inflammatory biomarkers and lung injury severity
scores, have been evaluated as predictors of disease progression and the requirement for …

[HTML][HTML] Development of therapeutic antibodies for the treatment of diseases

Z Wang, G Wang, H Lu, H Li, M Tang, A Tong - Molecular biomedicine, 2022 - Springer
Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in
1986, 165 antibody drugs have been approved or are under regulatory review worldwide …