An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked
to familial early onset forms of dementia. Mutation screening in these genes has been …

Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset
Alzheimer's disease (LOAD), but little has been done on a genome-wide scale to identify …

Objectives To evaluate the association of genetic variation with late-onset Alzheimer
disease (AD) in African Americans, including genes implicated in recent genome-wide …

Background Mild cognitive impairment (MCI) and pre-MCI have been proposed as stages
preceding Alzheimer's disease (AD) dementia. We assessed descendants of individuals …

Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD)
is complex, with significant contributions from both genes and environmental factors. Recent …

To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a
3-stage genome-wide association study (GWAS) using three populations: Japanese from …

Objective: Recent genome-wide association studies (GWAS) of late-onset Alzheimer
disease (LOAD) identified 9 novel risk loci. Discovery of functional variants within genes at …