Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

HMG-CoA reductase inhibitors (statins) dose-dependently lower both the level of low-
density lipoprotein cholesterol and risk of cardiovascular disease. In 2004, the UK approved …

Mounting research evidence demonstrates a significant negative impact of circadian
disruption on human health. Shift work, chronic jet lag and sleep disturbances are …

Living organisms have adapted to the daily rotation of the earth and regular changes in the
light environment. Life forms anticipate environmental transitions, adapt their own …

Exercise is an effective strategy to prevent and improve obesity and related metabolic
diseases. Exercise increases the metabolic demand in the body. Although many of the …

Background Chronobiology is devoted to the study of biological rhythms. It is possible that a
given medication may be therapeutic and safe when administered at some time, but …

Background Evidence about the optimal time of day at which to administer statins is lacking.
Objective The objective of this study is to synthesize evidence about effects of morning vs …

Although much has been learned about circadian clocks and rhythms over the past few
decades, translation of this foundational science underlying the temporal regulation of …

Introduction: The beneficial effects of glucocorticoids are highly regarded in the treatment of
inflammatory diseases. In rheumatoid arthritis, these drugs are widely used because they …

Hospital to Home is a quality‐based initiative led by the A merican C ollege of C ardiology
and the I nstitute for H ealthcare I mprovement, aimed at reducing 30‐day hospital …