Parkinson's disease (PD) is a slowly progressive neurodegenerative disease characterized
by α-synuclein aggregation and dopaminergic neuronal death. Recent evidence suggests …

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain.
Using a knockin mouse line in which a Td-tomato reporter is incorporated into the …

Mutations in PRKN cause the second most common genetic form of Parkinson's disease
(PD)—a debilitating movement disorder that is on the rise due to population aging in the …

The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …

Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature in probands affected by schizophrenia (SCZ). Evidence shows that SCZ and …

Neurodegenerative diseases are progressive brain disorders characterized by inexorable
synaptic dysfunction and neuronal loss. Since the most consistent risk factor for developing …

In the last decades, important progress has been achieved in the understanding of the
neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise …

Microglia, the resident immune cells of the central nervous system, play a critical role in
maintaining brain homeostasis. However, in neurodegenerative conditions, microglial cells …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder (NDD). In the
central nervous system (CNS), immune cells like microglia could reprogram intracellular …