The ADAM metalloproteinases

DR Edwards, MM Handsley, CJ Pennington - Molecular aspects of …, 2008 - Elsevier
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

Snake venom metalloproteinases

FS Markland Jr, S Swenson - Toxicon, 2013 - Elsevier
Recent proteomic analyses of snake venoms show that metalloproteinases represent major
components in most of the Crotalid and Viperid venoms. In this chapter we discuss the …

Accurate prediction of protein structures and interactions using a three-track neural network

M Baek, F DiMaio, I Anishchenko, J Dauparas… - Science, 2021 - science.org
DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin–mediated cellular injury

GA Wilke, JB Wardenburg - Proceedings of the National …, 2010 - National Acad Sciences
Staphylococcus aureus α-hemolysin (Hla), a potent cytotoxin, plays an important role in the
pathogenesis of staphylococcal diseases, including those caused by methicillin-resistant …

The ADAMs: signalling scissors in the tumour microenvironment

G Murphy - Nature Reviews Cancer, 2008 - nature.com
Over the last few years disintegrin metalloproteinases of the Adam (a disintegrin and
metalloproteinase) family have been associated with the process of proteolytic'shedding'of …

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

TS Kang, D Georgieva, N Genov… - The FEBS …, 2011 - Wiley Online Library
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

[HTML][HTML] Snake venom metalloproteinases (SVMPs): a structure-function update

OT Olaoba, PK Dos Santos, HS Selistre-de-Araujo… - Toxicon: X, 2020 - Elsevier
Snake venom metalloproteinases (SVMPs) represent a diverse group of multi-domain
proteins with several biological activities such as the ability to induce hemorrhage …

Ectodomain shedding and ADAMs in development

S Weber, P Saftig - Development, 2012 - journals.biologists.com
Proteolytic enzymes belonging to the A Disintegin And Metalloproteinase (ADAM) family are
able to cleave transmembrane proteins close to the cell surface, in a process referred to as …

[图书][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shopping" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom …

JW Fox, SMT Serrano - The FEBS journal, 2008 - Wiley Online Library
As more data are generated from proteome and transcriptome analyses of snake venoms,
we are gaining an appreciation of the complexity of the venoms and, to some degree, the …