SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …

MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …

Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

R Dey, B Bishayi - Cellular and Molecular Neurobiology, 2024 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is primarily a respiratory disease causing a
worldwide pandemic in the year of 2019. SARS‐CoV‐2 is an enveloped, positive-stranded …

Deficient GABABergic and glutamatergic excitability in the motor cortex of patients with long-COVID and cognitive impairment

P Manganotti, M Michelutti, G Furlanis, M Deodato… - Clinical …, 2023 - Elsevier
Objective Attention, working memory and executive processing have been reported to be
consistently impaired in Neuro-Long coronavirus disease (COVID). On the hypothesis of …

Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of …

MA Erickson, AF Logsdon, EM Rhea… - Brain, behavior, and …, 2023 - Elsevier
COVID-19 and especially Long COVID are associated with severe CNS symptoms and may
place persons at risk to develop long-term cognitive impairments. Here, we show that two …

[HTML][HTML] Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

ML Wu, C Xie, X Li, J Sun, J Zhao… - Frontiers in Cellular and …, 2024 - frontiersin.org
SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain
barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory …

[HTML][HTML] The Influence of Microglia on Neuroplasticity and Long-Term Cognitive Sequelae in Long COVID: Impacts on Brain Development and Beyond

LS Chagas, CA Serfaty - International Journal of Molecular Sciences, 2024 - mdpi.com
Microglial cells, the immune cells of the central nervous system, are key elements regulating
brain development and brain health. These cells are fully responsive to stressors …

[HTML][HTML] Flurona: the first autopsied case

II Jeican, D Gheban, A Mariș, S Albu, M Aluaș… - Medicina, 2023 - mdpi.com
COVID-19-associated coinfections increase the patient's risk of developing a severe form of
the disease and, consequently, the risk of death. The term “flurona” was proposed to …

L'hypométabolisme cérébral en TEP au 18F-FDG dans le COVID long

E Guedj, P Dudouet, F Goehringer, T Horowitz… - Bulletin de l'Académie …, 2023 - Elsevier
Résumé Un profil individuel d'hypométabolisme glucidique a été rapporté, au repos en
imagerie TEP cérébrale au 18 F-FDG, chez les patients présentant un COVID long avec …

Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

AK Verma, S Lowery, LC Lin, E Duraisami… - bioRxiv, 2024 - biorxiv.org
Post-Acute Sequelae of COVID-19 (PASC) encompasses persistent neurological symptoms,
including olfactory and autonomic dysfunction. Here, we report chronic neurological …