[HTML][HTML] A targeted multi-omic analysis approach measures protein expression and low-abundance transcripts on the single-cell level
High-throughput single-cell RNA sequencing (scRNA-seq) has become a frequently used
tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and …
tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and …
[HTML][HTML] Microbiota-induced type I interferons instruct a poised basal state of dendritic cells
L Schaupp, S Muth, L Rogell, M Kofoed-Branzk… - Cell, 2020 - cell.com
Environmental signals shape host physiology and fitness. Microbiota-derived cues are
required to program conventional dendritic cells (cDCs) during the steady state so that they …
required to program conventional dendritic cells (cDCs) during the steady state so that they …
Metabolic reprograming shapes neutrophil functions in severe COVID‐19
R Borella, S De Biasi, A Paolini… - European Journal of …, 2022 - Wiley Online Library
To better understand the mechanisms at the basis of neutrophil functions during SARS‐CoV‐
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
C Ferreira, L Barros, M Baptista, B Blankenhaus… - Nature …, 2020 - nature.com
Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells,
have a critical role in protective immunity in tissues, are more efficacious when elicited after …
have a critical role in protective immunity in tissues, are more efficacious when elicited after …
[HTML][HTML] Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues
SM Millard, O Heng, KS Opperman, A Sehgal… - Cell reports, 2021 - cell.com
Mouse hematopoietic tissues contain abundant tissue-resident macrophages that support
immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize …
immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize …
[HTML][HTML] Imbalanced immune response of T-cell and B-cell subsets in patients with moderate and severe COVID-19
A Golovkin, O Kalinina, V Bezrukikh, A Aquino… - Viruses, 2021 - mdpi.com
Background: The immunological changes associated with COVID-19 are largely unknown.
Methods: Patients with COVID-19 showing moderate (n= 18; SpO2> 93%, respiratory rate> …
Methods: Patients with COVID-19 showing moderate (n= 18; SpO2> 93%, respiratory rate> …
Cell‐mediated and humoral adaptive immune responses to SARS‐CoV‐2 are lower in asymptomatic than symptomatic COVID‐19 patients
A Mazzoni, L Maggi, M Capone… - European Journal of …, 2020 - Wiley Online Library
The characterization of cell‐mediated and humoral adaptive immune responses to SARS‐
CoV‐2 is fundamental to understand COVID‐19 progression and the development of …
CoV‐2 is fundamental to understand COVID‐19 progression and the development of …
Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer
Y Zheng, Z Wang, S Wei, Z Liu, G Chen - Cancer letters, 2021 - Elsevier
Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an
insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor …
insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor …
[HTML][HTML] Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis
R Yao, Z Li, L Wang, Y Li, L Zheng, N Dong, Y Wu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Evident immunosuppression has been commonly seen among septic patients,
and it is demonstrated to be a major driver of morbidity. Nevertheless, a comprehensive view …
and it is demonstrated to be a major driver of morbidity. Nevertheless, a comprehensive view …
[HTML][HTML] Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
Immune checkpoint inhibitors are used for treating patients with metastatic melanoma. Since
the response to treatment is variable, biomarkers are urgently needed to identify patients …
the response to treatment is variable, biomarkers are urgently needed to identify patients …