The development of maillard reaction, and advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling inhibitors as novel therapeutic strategies for …

CY Shen, CH Lu, CH Wu, KJ Li, YM Kuo, SC Hsieh… - Molecules, 2020 - mdpi.com
Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of
macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and …

AGE/RAGE in diabetic kidney disease and ageing kidney

XQ Wu, DD Zhang, YN Wang, YQ Tan, XY Yu… - Free Radical Biology …, 2021 - Elsevier
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

Advanced glycation end products and diabetes mellitus: mechanisms and perspectives

M Khalid, G Petroianu, A Adem - Biomolecules, 2022 - mdpi.com
Persistent hyperglycemic state in type 2 diabetes mellitus leads to the initiation and
progression of non-enzymatic glycation reaction with proteins and lipids and nucleic acids …

Cereal polyphenols inhibition mechanisms on advanced glycation end products and regulation on type 2 diabetes

L Dong, Y Li, Q Chen, Y Liu, Z Wu, D Pan… - Critical Reviews in …, 2024 - Taylor & Francis
Advanced glycation end products (AGEs), the products of non-enzymatic browning reactions
between the active carbonyl groups of reducing sugars and the free amines of amino acids …

A role for advanced glycation end products in molecular ageing

K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

Vitamin B6 and diabetes: relationship and molecular mechanisms

E Mascolo, F Vernì - International journal of molecular sciences, 2020 - mdpi.com
Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of
glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of …

Accumulation of advanced glycation end-products in the body and dietary habits

A Zawada, A Machowiak, AM Rychter, AE Ratajczak… - Nutrients, 2022 - mdpi.com
The formation of advanced glycation end-products (AGE) in tissues is a physiological
process; however, excessive production and storage are pathological and lead to …

Research advances on the damage mechanism of skin glycation and related inhibitors

W Zheng, H Li, Y Go, XH Chan, Q Huang, J Wu - Nutrients, 2022 - mdpi.com
Our skin is an organ with the largest contact area between the human body and the external
environment. Skin aging is affected directly by both endogenous factors and exogenous …

Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice

X Liu, D Liu, G Lin, Y Wu, L Gao, C Ai, Y Huang… - International Journal of …, 2019 - Elsevier
Oligosaccharides from green algae Ulva lactuca (ULO) and Enteromorpha prolifera (EPO)
were used for investigation of anti-ageing effects and the underlying mechanism in SAMP8 …

Dietary AGEs as exogenous boosters of inflammation

ME Garay-Sevilla, A Rojas, M Portero-Otin, J Uribarri - Nutrients, 2021 - mdpi.com
Most chronic modern non-transmissible diseases seem to begin as the result of low-grade
inflammation extending over prolonged periods of time. The importance of diet as a source …