Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Network pharmacology approach for medicinal plants: review and assessment

F Noor, M Tahir ul Qamar, UA Ashfaq, A Albutti… - Pharmaceuticals, 2022 - mdpi.com
Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …

Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis

W Zhou, H Zhang, X Wang, J Kang, W Guo, L Zhou… - Phytomedicine, 2022 - Elsevier
Background Moluodan (MLD) is a traditional Chinese patent medicine for the treatment of
chronic atrophic gastritis (CAG). However, the mechanism of action (MoA) of MLD for …

[HTML][HTML] Wumei Wan attenuates angiogenesis and inflammation by modulating RAGE signaling pathway in IBD: Network pharmacology analysis and experimental …

Z Duan, Y Wang, Z Lu, L Tian, ZQ Xia, K Wang, T Chen… - Phytomedicine, 2023 - Elsevier
Abstract Background Wumei Wan (WMW) has been used to address digestive disorder for
centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis …

From traditional ethnopharmacology to modern natural drug discovery: A methodology discussion and specific examples

S Pirintsos, A Panagiotopoulos, M Bariotakis… - Molecules, 2022 - mdpi.com
Ethnopharmacology, through the description of the beneficial effects of plants, has provided
an early framework for the therapeutic use of natural compounds. Natural products, either in …

Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine

P Zhang, D Zhang, W Zhou, L Wang… - Briefings in …, 2024 - academic.oup.com
Network pharmacology (NP) provides a new methodological perspective for understanding
traditional medicine from a holistic perspective, giving rise to frontiers such as traditional …

Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway

Y Zhang, Z Mengnan, LI Benke, B Zhang… - Chinese Journal of …, 2023 - Elsevier
This study aimed to investigate the effect and mechanisms of Ephedra Herb (EH) extract on
adriamycin-induced nephrotic syndrome (NS), providing an experimental basis for the …

Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway

Z Chen, J Gu, S Lin, Z Xu, H Xu, J Zhao, P Feng… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Saffron, the dried stigma of Crocus sativus L., has a long
history of use in the treatment of depression in traditional Chinese medicine and Islamic …

Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol

W Jiao, S Mi, Y Sang, Q Jin, B Chitrakar, X Wang… - Food Chemistry, 2022 - Elsevier
This study explored the anti-obesity effect of 6-shogaol and the underlying mechanisms by
using Network pharmacology for the prediction and verification of molecular targets and …

Based on network pharmacology and in vitro experiments to prove the effective inhibition of myocardial fibrosis by Buyang Huanwu decoction

T Wang, X Jiang, Y Ruan, J Zhuang, Y Yin - Bioengineered, 2022 - Taylor & Francis
Among cardiovascular diseases, myocardial fibrosis (MF) is a major pathological change
underlying heart failure and is associated with a high mortality rate. However, the molecular …