ABSTRACT A State of the Art lecture titled" Immunothrombosis in Neurovascular Diseases" was presented at the ISTH congress in 2023. Despite significant clinical advancements in …
Ischemic stroke is one of the leading causes of death and disability. Occlusion and reperfusion of cerebral blood vessels (ie, ischemia/reperfusion (I/R) injury) generates …
TM Errington - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
Center for Open Science, Charlottesville, Virginia, USA. Research is cumulative. New investigations build on, challenge, or qualify claims based on prior evidence. When we have …
A Morais, T Imai, X Jin, JJ Locascio… - Circulation …, 2023 - ahajournals.org
BACKGROUND: The SPAN trial (Stroke Preclinical Assessment Network) is the largest preclinical study testing acute stroke interventions in experimental focal cerebral ischemia …
JP Broderick, EA Mistry - Stroke, 2024 - ahajournals.org
The basic question that clinical trials try to answer for patients and health care providers is whether a therapy has a positive biologic effect that either prevents disease or improves the …
M Pérez-Mato, E López-Arias, A Bugallo-Casal… - Neuroscience, 2024 - Elsevier
The constant failure of new neuroprotective therapies for ischemic stroke has partially halted the search for new therapies in recent years, mainly because of the high investment risk …
A Alshammari, B Pillai, P Kamat, TW Jones… - Translational Stroke …, 2024 - Springer
Hypertension and aging are leading risk factors for stroke and vascular contributions to cognitive impairment and dementia (VCID). Most animal models fail to capture the complex …
H Tian, F Tian, D Ma, B Xiao, Z Ding, X Zhai… - Molecular …, 2024 - Springer
Ischemic stroke (IS) is a leading cause of death and disability worldwide. Tissue plasminogen activator (tPA) administration and mechanical thrombectomy are the main …