Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after
myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the …

Cardiovascular diseases are predicted to be the most common cause of death worldwide by
2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Environmental stresses converge on the mitochondria that can trigger or inhibit cell death.
Excitable, postmitotic cells, in response to sublethal noxious stress, engage mechanisms …

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15
minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 …

Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

The mitochondrial permeability transition is a key event in cell death. Intense research efforts
have been focused on elucidating the molecular components of the mitochondrial …

Case presentation: SB is a 48-year-old man who suffered an acute anterior myocardial
infarction and received fibrinolytic therapy. The patient died 12 hours after reperfusion. KR is …

Objectives: The goal of this study was to assess the interaction between heart failure (HF)
etiology and response to milrinone in decompensated HF. Background: Etiology has …