Protein post-translational modifications (PTMs) are chemical modifications of a protein after
its translation. Owing to its play an important role in deep understanding of various biological …

Sumoylation is a reversible posttranslational modification that plays roles in many
processes, including transcriptional regulation, cell division, chromosome integrity, and DNA …

Most modern tools used to predict sites of small ubiquitin-like modifier (SUMO) binding
(referred to as SUMOylation) use algorithms, chemical features of the protein, and …

Background Glycation is a one of the post-translational modifications (PTM) where sugar
molecules and residues in protein sequences are covalently bonded. It has become one of …

Recent studies have revealed various functions for the small ubiquitin-related modifier
(SUMO) in diverse biological phenomena, such as regulation of cell division, DNA repair …

DNA topoisomerase II (TOP2) plays a pivotal role in faithful chromosome separation through
its strand-passaging activity that resolves tangled genomic DNA during mitosis. Additionally …

Sumoylation is one of the most essential mechanisms of reversible protein post-translational
modifications and is a crucial biochemical process in the regulation of a variety of important …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
death of motor neurons. While the exact molecular and cellular basis for motor neuron death …

Neurotransmitter release from the presynaptic terminal is under very precise spatial and
temporal control. Following neurotransmitter release, synaptic vesicles are recycled by …

Abstract Forkhead Box P (FOXP) transcriptional repressors play a major role in brain
development and their dysfunction leads to human cognitive disorders. However, little is …