Posttranslational modifications of proteins possess key functions in the regulation of various
cellular processes. While they facilitate fast, location-specific and transient reactions to …

Background Protein sumoylation is an essential dynamic, reversible post translational
modification that plays a role in dozens of cellular activities, especially the regulation of gene …

DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with
activity implicated in the resolution of tangled DNA at centromeres before anaphase onset …

Recombination and pairing of homologous chromosomes are critical for bivalent formation
in meiotic prophase. In many organisms, including yeast, mammals, and plants, pairing and …

The modification of proteins by the addition of ubiquitin and other ubiquitin-like proteins
(UBLs) is involved in a wide range of cellular processes including cell cycle progression, the …

Type II topoisomerase enzymes are essential for resolving DNA topology problems arising
through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of …

Post-translational modifications (PTMs) are vital cellular control mechanism, which affect
protein properties, including folding, conformation, activity and consequently, their functions …

Small ubiquitin-like modifier (SUMO) participates in a reversible posttranslational
modification process (SUMOylation) that regulates a wide variety of cellular processes and …

DNA methylation regulates gene expression through a complex network of protein–protein
and protein–DNA interactions in chromatin. The maintenance methylase, DNMT1 (DNA …

Rationale: The highly conserved NOTCH (neurogenic locus notch homolog protein)
signaling pathway functions as a key cell–cell interaction mechanism controlling cell fate …