Population studies have shown that treatment with the antidiabetic biguanide metformin
significantly reduced cancer risk. In our animal studies, metformin delayed the onset of …

Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are
important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases …

Potentially carcinogenic compounds may cause cancer through direct DNA damage or
through indirect cellular or physiological effects. To study possible carcinogens, the fields of …

Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …

It is essential to life that a balance is maintained between processes that produce ATP and
those that consume it. An obvious way to do this would be to have systems that monitor the …

The metabolic features of tumor cells diverge from those of normal cells. Otto Warburg was
the first to observe that cancer cells dramatically increase their glucose consumption to …

Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …

Background Women have a high risk of frailty independently of age and menopause state.
Diabetes and hypertension increase the risk of frailty and cognitive impairment. Metformin …

Covering: up to the end of June 2013 Ageing is a complex molecular process driven by
diverse molecular pathways and biochemical events that are promoted by both …

Metabolism plays a significant role in the regulation of aging at different levels, and
metabolic reprogramming represents a major driving force in aging. Metabolic …