[HTML][HTML] Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination

S Lebu, W Kibone, CC Muoghalu… - PLoS neglected …, 2023 - journals.plos.org
Researchers have raised the possibility that soil-transmitted helminth (STH) infections might
modify the host's immune response against other systemic infections. STH infections can …

[HTML][HTML] How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

I Camaya, B O'Brien, S Donnelly - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes is the fastest growing chronic disease globally, with prevalence increasing at a
faster rate than heart disease and cancer. While the disease presents clinically as chronic …

Engineering therapeutic monoclonal antibodies

CA Stone Jr, BW Spiller, SA Smith - Journal of Allergy and Clinical …, 2023 - Elsevier
The use of human antibodies as biologic therapeutics has revolutionized patient care
throughout fields of medicine. As our understanding of the many roles antibodies play within …

[HTML][HTML] The relationship of parasite allergens to allergic diseases

L Caraballo, K Llinás-Caballero - Current allergy and asthma reports, 2023 - Springer
Abstract Purpose of Review Helminth infections modify the natural history of allergic
diseases, by either decreasing or increasing their symptoms. Several helminth components …

Helminths' therapeutic potential to treat intestinal barrier dysfunction

TC Mules, S Inns, G Le Gros - Allergy, 2023 - Wiley Online Library
The intestinal barrier is a dynamic multi‐layered structure which can adapt to environmental
changes within the intestinal lumen. It has the complex task of allowing nutrient absorption …

Beyond schistosomiasis: unraveling co-infections and altered immunity

DJ Perera, C Koger-Pease, K Paulini… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Schistosomiasis is a neglected tropical disease caused by the helminth Schistosoma spp.
and has the second highest global impact of all parasites. Schistosoma are transmitted …

[HTML][HTML] Importance of adjuvant selection in tuberculosis vaccine development: exploring basic mechanisms and clinical implications

HG Choi, KW Kwon, SJ Shin - Vaccine: X, 2023 - Elsevier
The global emergency of unexpected pathogens, exemplified by SARS-CoV-2, has
emphasized the importance of vaccines in thwarting infection and curtailing the progression …

Controlled hookworm infection for medication-free maintenance in patients with ulcerative colitis: a pilot, double-blind, randomized control trial

TC Mules, B Lavender, K Maclean… - Inflammatory bowel …, 2024 - academic.oup.com
Background Human hookworm has been proposed as a treatment for ulcerative colitis (UC).
This pilot study assessed the feasibility of a full-scale randomized control trial examining …

Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?

F Giombi, GM Pace, F Pirola, M Cerasuolo… - International Journal of …, 2024 - mdpi.com
Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving
from a phenotypical classification towards an “endotype-based” definition that places more …

[HTML][HTML] Infection with soil-transmitted helminths and their impact on coinfections

J Schlosser-Brandenburg, A Midha, RM Mugo… - Frontiers in …, 2023 - frontiersin.org
The most important soil-transmitted helminths (STHs) affecting humans are roundworms,
whipworms, and hookworms, with a large proportion of the world's population infected with …