Although many children with idiopathic nephrotic syndrome (INS) respond initially to steroid
therapy, repeated courses for patients with relapses often cause significant steroid toxicity …

Nephrotic syndrome is one of the most common paediatric glomerular diseases, with an
incidence of around two per 100 000 children per year. Corticosteroids are the mainstay of …

In this multicenter, open-label, randomized controlled trial, we determined whether 2-month
prednisolone therapy for steroid-sensitive nephrotic syndrome was inferior or not to 6-month …

B-cell–depletion therapy with rituximab is efficacious against steroid-dependent nephrotic
syndrome (NS) in children and adults. Safety data are limited. Results of small studies have …

Rituximab (RTX) has been successfully used as a rescue therapy in children with steroid-
dependent nephrotic syndrome (SDNS). However, little is known regarding maintenance …

The injury and dysfunction of the femoral head microvascular endothelial cells are
associated with the pathogenesis of glucocorticoid‐induced osteonecrosis of the femoral …

Background Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is closely
associated with the dysfunction of the bone microvascular endothelial cells (BMECs). The …

Idiopathic nephrotic syndrome (INS) has been studied for decades in attempt to understand
the physiopathological mechanisms explaining the disease. It is recognized as a …

Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections
and immunological diseases, however they may cause steroid‑induced avascular necrosis …

Apoptosis and DNA oxidative damage serve significant roles in the pathogenesis of steroid‑
induced femoral head necrosis. Vitamin E demonstrates anti‑apoptotic and anti‑oxidant …