[HTML][HTML] Roles of RNA methylation on tumor immunity and clinical implications

M Zhang, J Song, W Yuan, W Zhang, Z Sun - Frontiers in immunology, 2021 - frontiersin.org
RNA methylation is a kind of RNA modification that exists widely in eukaryotes and
prokaryotes. RNA methylation occurs not only in mRNA but also in ncRNA. According to the …

[HTML][HTML] The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

Y Gu, X Wu, J Zhang, Y Fang, Y Pan, Y Shu, P Ma - Molecular Therapy, 2021 - cell.com
The tumor microenvironment (TME), controlled by intrinsic mechanisms of carcinogenesis
and epigenetic modifications, has, in recent years, become a heavily researched topic. The …

[HTML][HTML] Expression of m6A regulators correlated with immune microenvironment predicts therapeutic efficacy and prognosis in gliomas

S Xu, L Tang, G Dai, C Luo, Z Liu - Frontiers in cell and …, 2020 - frontiersin.org
Background N6-methyladenosine (m6A) RNA methylation and tumor immune
microenvironment played crucial roles in cancer development. However, their association in …

[HTML][HTML] MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

M Du, Y Peng, Y Li, W Sun, H Zhu, J Wu, D Zong… - Cell Death …, 2022 - nature.com
Abstract N6-Methyladenosine (m6A) modification is the most abundant RNA modification in
eukaryotic cells. IGF2BP3, a well-known m6A reader, is deregulated in many cancers, but its …

[HTML][HTML] N6-Methyladenosine RNA modification in the tumor immune microenvironment: novel implications for immunotherapy

L Guo, H Yang, C Zhou, Y Shi, L Huang… - Frontiers in …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation is one of the most common modifications of RNA in
eukaryotic cells, and is mainly regulated by m6A methyltransferases (writers), m6A …

METTL14 Regulates Intestine Cellular Senescence through m6A Modification of Lamin B Receptor

Z Zhang, M Xue, J Chen, Z Wang, F Ju… - Oxidative Medicine …, 2022 - Wiley Online Library
N‐6‐Methyladenosine (m6A) modification is involved in multiple biological processes
including aging. However, the regulation of m6A methyltransferase‐like 14 (METTL14) in …

[HTML][HTML] Integrative transcriptomic, proteomic and functional analysis reveals ATP1B3 as a diagnostic and potential therapeutic target in hepatocellular carcinoma

S Lu, S Cai, X Peng, R Cheng, Y Zhang - Frontiers in immunology, 2021 - frontiersin.org
The Na+/K+-ATPase (NKA), has been proposed as a signal transducer involving various
pathobiological processes, including tumorigenesis. However, the clinical relevance of NKA …

[HTML][HTML] RNA N 6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Q Dang, B Shao, Q Zhou, C Chen, Y Guo… - Frontiers in …, 2021 - frontiersin.org
Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and
a lethal challenge for cancer patients. N 6-methyladenosine (m6A), the most prevailing …

[HTML][HTML] m6A regulators mediated methylation modification patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma

Z Liu, J He, J Han, J Yang, W Liao, N Chen - Frontiers in Immunology, 2022 - frontiersin.org
Background The role of RNA N6-methyladenosine (m6A) modification in tumor progression
and metastasis has been demonstrated. Nonetheless, potential biological function of m6A …

Identification of tumor-infiltrating immune cells and microenvironment-relevant genes in nasopharyngeal carcinoma based on gene expression profiling

Z Zou, Y Ha, S Liu, B Huang - Life Sciences, 2020 - Elsevier
Aims The purpose of this study was to investigate the prognostic significance of tumor-
infiltrating immune cells and microenvironment-relevant genes in nasopharyngeal …