Partial cellular reprogramming via transient expression of Oct4, Sox2, Klf4, and c‐Myc
induces rejuvenation and reduces aged‐cell phenotypes. In this study, we found that …

The global aging situation is severe, and the medical pressures associated with aging
issues should not be underestimated. The need and feasibility of studying aging and …

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental polygenic disorder
that affects more than 5% of children and adolescents around the world. Genetic and …

Aging is defined as a complex, multifaceted degenerative process that causes a gradual
decline of physiological functions and a rising mortality risk with time. Stopping senescence …

Aging clocks have provided one of the most significant recent breakthroughs in the biology
of aging. Such clocks allow the determination of chronological and increasingly also …

Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive
capacity of the organism, as a result of which the body becomes less adaptable to stressful …

Motivation Aging is intricately linked to diseases and mortality. It is reflected in molecular
changes across various tissues which can be leveraged for the development of biomarkers …

Ageing is known to be the primary risk factor for most neurodegenerative diseases, including
Alzheimer's disease, Parkinson's disease and Huntington's disease. They are currently …

Aging manifests as progressive dysfunction culminating in death. The diversity of cell types
is a challenge to the precise quantification of aging and its reversal. Here we develop a suite …

During embryonic development, cells gradually restrict their developmental potential as they
exit pluripotency and differentiate into various cell types. The POU transcription factor Oct4 …