Stem cell rejuvenation by restoration of youthful metabolic compartmentalization

AR Mendelsohn, JW Larrick - Rejuvenation Research, 2021 - liebertpub.com
Stem cell dysfunction is a hallmark of aging. Much recent study suggests that epigenetic
changes play a critical role in the loss of stem cell function with age. However, the …

Epigenetic Alterations in Pancreatic Cancer

CZ Bulbul, BM Volkan, S Soner - Cancer Epigenetics, 2023 - Springer
The occurrence of pancreatic cancer (PC) is presented to have risen in the past few years.
Pancreatic cancer includes 5% of all cancer-related deaths and almost 2% of existing …

Safety Issues Related to Pluripotent Stem Cell-Based Therapies: Tumour Risk

S Hillenius, J Montilla-Rojo, TF Eleveld… - Pluripotent Stem Cell …, 2024 - Springer
As the exciting era of regenerative medicine has dawned, considerable efforts aim to further
develop human pluripotent stem cell (hPSC)-based therapies for a plethora of diseases …

[HTML][HTML] Combined ketogenic diet and walking exercise interventions in community older frailty and skeletal muscle sarcopenia

JP Wu - Frailty and Sarcopenia-Recent Evidence and New …, 2021 - intechopen.com
The ketogenic diet and walking exercise training interventions are two key public health
lifestyle factors. The potential of combined lifestyle factors interventions focused on getting to …

[PDF][PDF] Cellular Reprogramming, Transdifferentiation and Alleviation of the Aging Pathology

G Mohit, JMS Mohammed, MA Akbarsha… - Research Journal of …, 2024 - researchgate.net
Cellular reprogramming and transdifferentiation have emerged as transformative
technologies in regenerative medicine, holding significant promise for addressing age …

Involvement of the Wnt Signaling in Methylphenidate (Ritalin) Treatment of ADHD

CM Yde Ohki - 2024 - zora.uzh.ch
As a highly prevalent neurodevelopmental disorder, attention-deficit hyperactivity disorder
(ADHD) mostly affects children and adolescents across the globe, and it is regarded as a …

IMPACT OF AGING ON MAMMALIAN INTRA-AND EXTRA-CELLULAR ENVIRONMENTS

T De Iorio - 2024 - air.unimi.it
Aging is a physiological process characterized by a gradual decline in cell, tissue, and
organ functions. Although a significant amount of information is available on the senescence …

Quantifying the ageing methylome: a multi-tissue map in humans

K Seale - 2023 - vuir.vu.edu.au
The epigenome is a dynamic system of chemical modifications that operate to control
chromatin structure and regulate gene activity without altering the underlying DNA …

Global signatures of the human mesenchymal stromal cell secretome: A comparative proteomic analysis of iPSC and tissue-derived MSC secretomes before and after …

J Frith, M Hodgson-Garms, M Moore, M Martino, K Kelly - 2024 - researchsquare.com
Multipotent mesenchymal stromal cells (MSCs) are one of the most heavily studied cell
therapies worldwide, with much of their therapeutic potential underpinned by their complex …

Dipping a toe in the fountain of youth

A Markel, GQ Daley - Nature Aging, 2022 - nature.com
In cultured cells and in mice with accelerated aging, brief bursts of Yamanaka
reprogramming factors reverse some molecular and functional deficits of aging without …