SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
Novel sofosbuvir derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective
A Alrehaily, AA Elfiky, IM Ibrahim, MN Ibrahim… - Scientific Reports, 2023 - nature.com
The human coronavirus, SARS-CoV-2, had a negative impact on both the economy and
human health, and the emerging resistant variants are an ongoing threat. One essential …
human health, and the emerging resistant variants are an ongoing threat. One essential …
Recognition through GRP78 is enhanced in the UK, South African, and Brazilian variants of SARS-CoV-2; An in silico perspective
New SARS-CoV-2 variants emerged in the United Kingdom and South Africa in December
2020 in concomitant with the Brazillian variant in February 2021 (B. 1.1. 248 lineage) and …
2020 in concomitant with the Brazillian variant in February 2021 (B. 1.1. 248 lineage) and …
Application of artificial intelligence (AI) to control COVID-19 pandemic: Current status and future prospects
S Ashique, N Mishra, S Mohanto, A Garg… - Heliyon, 2024 - cell.com
The impact of the coronavirus disease 2019 (COVID-19) pandemic on the everyday
livelihood of people has been monumental and unparalleled. Although the pandemic has …
livelihood of people has been monumental and unparalleled. Although the pandemic has …
Combination Therapy of Ledipasvir and Itraconazole in the Treatment of COVID‐19 Patients Coinfected with Black Fungus: An In Silico Statement
The manuscript mainly aimed at providing clues on improving the innate immunity of
coronavirus patients and safeguarding them from both new mutant strains and black fungus …
coronavirus patients and safeguarding them from both new mutant strains and black fungus …
Effect of sofosbuvir-based treatment on clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials
CK Hsu, CY Chen, WC Chen, CC Lai, SH Hung… - International Journal of …, 2022 - Elsevier
This systematic review and meta-analysis examined the efficacy of sofosbuvir-based
antiviral treatment against COVID-19 (coronavirus disease 2019). PubMed, Embase …
antiviral treatment against COVID-19 (coronavirus disease 2019). PubMed, Embase …
[HTML][HTML] COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated
disease COVID-19. Clinicians are continuously facing huge problems in the treatment of …
disease COVID-19. Clinicians are continuously facing huge problems in the treatment of …
Dual Targeting of RdRps of SARS-CoV-2 and the Mucormycosis-Causing Fungus: An in silico Perspective
AA Elfiky - Future Microbiology, 2022 - Taylor & Francis
During the past few months, mucormycosis has been associated with SARS-CoV-2
infections. Molecular docking combined with molecular dynamics simulation is utilized to test …
infections. Molecular docking combined with molecular dynamics simulation is utilized to test …
Molecular dynamics simulations and MM-GBSA reveal novel guanosine derivatives against SARS-CoV-2 RNA dependent RNA polymerase
According to the World Health Organization (WHO), SARS-CoV-2 is responsible for more
than 5 M deaths and is reported in 223 countries infecting 250+ M people. Despite the …
than 5 M deaths and is reported in 223 countries infecting 250+ M people. Despite the …