The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

It has recently been demonstrated that the marked increase in the systemic concentration of
cytokine interleukin‐6 (IL‐6) seen with exercise originates from the contracting limb and that …

The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his
article “IL-6: A Cytokine for Gerontologists,” indicated IL-6 as one of the main signaling …

Interleukin‐6 (IL‐6) is produced locally in working skeletal muscle and can account for the
increase in plasma IL‐6 during exercise. The production of IL‐6 during exercise is related to …

Chapter summary IL-6 is a pleiotropic cytokine with a wide range of biological activities in
immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared …

Abstract gp130 is a common signal transducer for the interleukin-6-related cytokines. To
delineate the gp130-mediated growth signal, we established a series of pro-B cell lines …

Interleukin-6 (IL-6), a member of the neuropoietic cytokine family, initially was described in
terms of its activities in the immune system and during inflammation. Accumulating evidence …

Cytokines are soluble glycoproteins that are produced by and mediate communication
between and within immune and nonimmune cells, organs and organ systems throughout …

Abstract Interleukin 6 (IL6) trans-signaling has emerged as a prominent regulator of immune
responses during both innate and acquired immunity. Regulation of IL6 trans-signaling is …

It has been suggested that interleukin-6 (IL-6) plays a key role in the pathogenesis of
rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints but also in the …