Epi-drugs in heart failure

E Gorica, SA Mohammed, S Ambrosini… - Frontiers in …, 2022 - frontiersin.org
Unveiling the secrets of genome's flexibility does not only foster new research in the field,
but also gives rise to the exploration and development of novel epigenetic-based therapies …

RNA modification m6Am: the role in cardiac biology

D Benak, F Kolar, L Zhang, Y Devaux, M Hlavackova - Epigenetics, 2023 - Taylor & Francis
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …

N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

Y Wu, D Jiang, H Zhang, F Yin, P Guo… - Frontiers in …, 2022 - frontiersin.org
Objectives This study aimed to identify key AAA-related m1A RNA methylation regulators
and their association with immune infiltration in AAA. Furthermore, we aimed to explore the …

29 m6A‐RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 …

M Liu, K Xu, F Saaoud, Y Shao, R Zhang… - Journal of …, 2022 - Wiley Online Library
We performed a database mining on 102 transcriptomic datasets for the expressions of 29
m6A‐RNA methylation (epitranscriptomic) regulators (m6A‐RMRs) in 41 diseases and …

Emerging role of epitranscriptomics in diabetes mellitus and its complications

X Geng, Z Li, Y Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) and its related complications are among the leading causes of
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …

m6A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension

P Liu, A Zhang, Z Ding, D Dai, B Li, SF Liu… - American Journal of …, 2022 - atsjournals.org
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
induced by human pulmonary arterial smooth muscle cell (HPASMC) proliferation …

Regulation of N6-methyladenosine after myocardial infarction

M Vausort, M Niedolistek, AI Lumley, M Oknińska… - Cells, 2022 - mdpi.com
Development of heart failure (HF) after myocardial infarction (MI) is responsible for
premature death. Complex cellular and molecular mechanisms are involved in this process …

Progress in epigenetic regulation of milk synthesis, with particular emphasis on mRNA regulation and DNA methylation

Q Xue, Y Huang, C Cheng, Y Wang, F Liao, Q Duan… - Cell Cycle, 2023 - Taylor & Francis
Inadequate milk secretion and a lack of nutrients in humans and mammals are serious
problems. It is of great significance to clarify the mechanisms of milk synthesis and treatment …

Comprehensive analysis of the expression of N6-methyladenosine RNA methylation regulators in pulmonary artery hypertension

H Zheng, J Hua, H Li, W He, X Chen, Y Ji, Q Li - Frontiers in Genetics, 2022 - frontiersin.org
Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by pulmonary vascular remodeling. The development of PAH involves N6-methyladenosine …

Oral squamous cell carcinoma gene patterns connected with RNA methylation for prognostic prediction

X Wu, J Tang, B Cheng - Oral Diseases, 2024 - Wiley Online Library
Objectives To determine whether m6A/m1A/m5C/m7G/m6Am/Ψ‐related genes influence the
prognosis of a patient with oral squamous cell carcinoma. Materials and Methods We …