Integrative computational modeling of the lymph node stromal cell landscape
Adaptive immune responses develop in secondary lymphoid organs such as lymph nodes
(LNs) in a well-coordinated series of interactions between migrating immune cells and …
(LNs) in a well-coordinated series of interactions between migrating immune cells and …
Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection
HP Mirsky, MJ Miller, JJ Linderman… - Journal of theoretical …, 2011 - Elsevier
Adaptive immunity is initiated in secondary lymphoid tissues when naive T cells recognize
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …
[HTML][HTML] Anatomy, lymph nodes
I Bujoreanu, V Gupta - 2020 - europepmc.org
The lymphatic system is composed of lymphatic vessels and lymphoid organs such as the
thymus, tonsils, lymph nodes, and spleen. These assist in acquired and innate immunity, in …
thymus, tonsils, lymph nodes, and spleen. These assist in acquired and innate immunity, in …
[图书][B] Immune system modelling and simulation
F Castiglione, F Celada - 2015 - books.google.com
This book describes a computational model of the immune system reaction, C-ImmSim. The
book presents the basic model as well as the various customizations to implement the …
book presents the basic model as well as the various customizations to implement the …
Hybrid approach to model the spatial regulation of T cell responses
Background Moving from the molecular and cellular level to a multi-scale systems
understanding of immune responses requires the development of novel approaches to …
understanding of immune responses requires the development of novel approaches to …
Mechanistic modeling and multiscale applications for precision medicine: theory and practice
Drug research, therapy development, and other areas of pharmacology and medicine can
benefit from simulations and optimization of mathematical models that contain a …
benefit from simulations and optimization of mathematical models that contain a …
Potential predictors of type-2 diabetes risk: machine learning, synthetic data and wearable health devices
Background The aim of a recent research project was the investigation of the mechanisms
involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the …
involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the …
Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens
In many immunological processes chemoattraction is thought to play a role in guiding cells
to their sites of action. However, based on in vivo two-photon microscopy experiments in the …
to their sites of action. However, based on in vivo two-photon microscopy experiments in the …
Multiscale modeling of the early CD8 T-cell immune response in lymph nodes: an integrative study
SA Prokopiou, L Barbarroux, S Bernard, J Mafille… - Computation, 2014 - mdpi.com
CD8 T-cells are critical in controlling infection by intracellular pathogens. Upon encountering
antigen presenting cells, T-cell receptor activation promotes the differentiation of naïve CD8 …
antigen presenting cells, T-cell receptor activation promotes the differentiation of naïve CD8 …
Computational approach to 3D modeling of the lymph node geometry
In this study we present a computational approach to the generation of the major geometric
structures of an idealized murine lymph node (LN). In this generation, we consider the major …
structures of an idealized murine lymph node (LN). In this generation, we consider the major …