Modeling the effect of high calorie diet on the interplay between adipose tissue, inflammation, and diabetes
V Prana, P Tieri, MC Palumbo… - … methods in medicine, 2019 - Wiley Online Library
Background. Type 2 diabetes (T2D) is a chronic metabolic disease potentially leading to
serious widespread tissue damage. Human organism develops T2D when the glucose …
serious widespread tissue damage. Human organism develops T2D when the glucose …
A multifaceted approach to modeling the immune response in tuberculosis
S Marino, JJ Linderman… - … : Systems Biology and …, 2011 - Wiley Online Library
Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis
(Mtb). No available vaccine is reliable and, although treatment exists, approximately 2 …
(Mtb). No available vaccine is reliable and, although treatment exists, approximately 2 …
IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8+ T cell-APC: a multiscale modeling study
X Gao, C Arpin, J Marvel, SA Prokopiou… - BMC systems …, 2016 - Springer
Abstract Background The CD8+ T cell immune response fights acute infections by
intracellular pathogens and, by generating an immune memory, enables immune responses …
intracellular pathogens and, by generating an immune memory, enables immune responses …
A global “imaging''view on systems approaches in immunology
The immune system exhibits an enormous complexity. High throughput methods such as the
“‐omic''technologies generate vast amounts of data that facilitate dissection of …
“‐omic''technologies generate vast amounts of data that facilitate dissection of …
Towards multiscale modeling of the CD8+ T cell response to viral infections
The CD8+ T cell response is critical to the control of viral infections. Yet, defining the CD8+ T
cell response to viral infections quantitatively has been a challenge. Following antigen …
cell response to viral infections quantitatively has been a challenge. Following antigen …
[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system
The lymph node (LN) is a vital organ of the lymphatic and immune system that enables
timely detection, response, and clearance of harmful substances from the body. Each LN …
timely detection, response, and clearance of harmful substances from the body. Each LN …
Immunogrid: towards agent-based simulations of the human immune system at a natural scale
M Halling-Brown, F Pappalardo… - … of the Royal …, 2010 - royalsocietypublishing.org
The ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model
of the human immune system—that is, one that reflects both the diversity and the relative …
of the human immune system—that is, one that reflects both the diversity and the relative …
Towards a multiscale model of acute HIV infection
Human Immunodeficiency Virus (HIV) infection of humans represents a complex biological
system and a great challenge to public health. Novel approaches for the analysis and …
system and a great challenge to public health. Novel approaches for the analysis and …
An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes
Although combined anti-retroviral therapy (cART) suppresses plasma HIV viremia below the
limit of detection in a majority of HIV patients, evidence is emerging that the distribution of …
limit of detection in a majority of HIV patients, evidence is emerging that the distribution of …
Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity
SC Johnson, J Frattolin, LT Edgar… - Journal of the …, 2021 - royalsocietypublishing.org
Swelling of lymph nodes (LNs) is commonly observed during the adaptive immune
response, yet the impact on T cell (TC) trafficking and subsequent immune response is not …
response, yet the impact on T cell (TC) trafficking and subsequent immune response is not …