Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the
balance of acetylation and deacetylation of lysine residues of histones and non-histone …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that
represent promising therapeutic targets for the treatment of numerous human diseases. Yet …

Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs,
such functional groups acquired even more notoriety in synthetic medicinal chemistry. The …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …

Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

The phenothiazine system was identified as a favorable cap group for potent and selective
histone deacetylase 6 (HDAC6) inhibitors. Here, we report the preparation and systematic …

Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone
and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free …